Poster
# 86
Poster |
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6th Internet World Congress for Biomedical Sciences |
Kirsten Culver(1), Henry Szechtman(2)
(1)(2)McMaster University - Hamilton. Canada
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[Neuroscience] |
As shown in Figure 1, quinpirole produced a robust sensitization in the QNP+SAL group, as evidenced by a 5-fold increase in locomotor activity on Injection 8, compared to Injection 1 (p<0.001, paired t-test). Clorgyline, regardless of whether administered via osmotic mini-pump or subcutaneous injection, blocked the induction of locomotor sensitization (Injection 1 vs Injection 8; p>0.05, paired t-test). Both groups of clorgyline treated rats (QNP+CLG and QNP+CLGinj) displayed an acute locomotor response to the test injection of quinpirole, no different from that of the SAL Control group (p>0.05), and significantly lower than the QNP sensitized group (p<0.05, Duncan multiple range test). This finding shows that clorgyline, regardless of whether it is administered continuously or intermittently, blocks the induction, rather than merely the expression of quinpirole-induced locomotor sensitization.
As shown in Figure 2, repeated injections of quinpirole reduced the percentage of time spent engaged in mouthing activity in the QNP+SAL group on Injection 8, compared to Injection 1 (p<0.05, paired t-test). In contrast, regardless of whether administered via osmotic mini-pump or subcutaneous injection, clorgyline significantly increased the percentage of time spent mouthing (Injection 1vs Injection 8; p<0.05, paired t-test). Both groups of clorgyline treated rats (QNP+CLG and QNP+CLGinj), engaged in significantly more mouthing activity on the test injection of quinpirole compared to the SAL Control and QNP+SAL groups (p<0.05, Duncan multiple range test). Mouthing activity occurred predominantly in the last 15 minutes of the testing period, and consisted primarily of self-directed behaviors such as nibbling of the tail and paws, and licking of the fur around the neck and chest (data not shown).
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[Neuroscience] |
