Kirsten Culver⁽¹⁾, Henry Szechtman^(2)
(1)(2)McMaster University - Hamilton. Canada

	[Neuroscience]

INTRODUCTION

Repeated administration of the D2/D3 receptor agonist, quinpirole (QNP), results in behavioral sensitization⁽⁵⁾; a progressive augmentation of the locomotor response to subsequent injections of the drug⁽⁴⁾. Recent studies have shown that monoamine oxidase inhibitors (MAOIs) such as clorgyline (CLG), inhibit the binding of quinpirole, but not that of the D2 receptor antagonist, spiperone, in rat striatal membranes^(2,3). These findings suggest that monoamine oxidase inhibitors posses a unique affinity for a MAOI displaceable quinpirole binding site (MQB) that is either labeled by quinpirole, or which modulates quinpirole binding at D2-like receptors^(2,3).

Behavioral studies have shown that continuous infusion of clorgyline blocks the induction of quinpirole-induced locomotor sensitization by a mechanism other than inhibition of the MAO enzyme, suggesting that the MQB site may be involved in sensitization to quinpirole ^(1,6,7).

The purpose of the present study was to determine whether intermittent injections of clorgyline would block quinpirole-induced locomotor sensitization as effectively as did the continuous infusion of clorgyline via osmotic mini-pump.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [FIGURES] [DISCUSSION AND CONCLUSIONS] [REFERENCES] [Discussion Board]

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	[Neuroscience]

Kirsten Culver, Henry Szechtman
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Last update: 12/01/00