Poster
# 86
Poster |
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6th Internet World Congress for Biomedical Sciences |
Kirsten Culver(1), Henry Szechtman(2)
(1)(2)McMaster University - Hamilton. Canada
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Contact address: |
Kirsten Culver McMaster University Health Science Centre Rm 4N7 1200 Main Street West Hamilton Ontario L8N 3Z5 Canada culverk@fhs.mcmaster.ca |
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[Neuroscience] |
The purpose of this study was to determine whether chronic intermittent injections of clorgyline would block quinpirole-induced locomotor sensitization as effectively as does clorgyline administered continuously via osmotic mini-pump. Rats were treated with chronic clorgyline via osmotic mini-pumps (1 mg/kg/day) or via subcutaneous injections (1 mg/kg), administered 90 min prior to each injection of quinpirole (0.5 mg/kg). Immediately following each quinpirole injection, animals were placed in activity monitors and their locomotor and mouthing activity was recorded for 90 min. clorgyline, regardless of whether it was administered intermittently or continuously, blocked the induction of quinpirole-induced locomotor sensitization, compared to quinpirole controls. To determine whether clorgyline did in fact block the induction of locomotor sensitization to quinpirole, or whether it simply blocked its expression, clorgyline treatment was discontinued after the 8th quinpirole injection and all groups received a test injection of quinpirole one week later. The locomotor response of rats treated intermittently or continuously with clorgyline was no different from an acute response, clearly indicating that quinpirole-induced locomotor sensitization was completely blocked in both clorgyline treated groups. Together, these results support the hypothesis that the induction of locomotor sensitization to quinpirole may involve the activation of a MAOI-displaceable quinpirole binding site (MQB).
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[Neuroscience] |
