Poster
# 86
Poster |
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6th Internet World Congress for Biomedical Sciences |
Kirsten Culver(1), Henry Szechtman(2)
(1)(2)McMaster University - Hamilton. Canada
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[Neuroscience] |
1. Results show that regardless of whether it is administered continuously or intermittently, clorgyline A) blocks the induction of locomotor sensitization to repeated injections of quinpirole, and B) induces sensitization of mouthing.
2. To the extent that the process of sensitization involves 4 discrete stages (trigger, induction, expression and maintenance), the finding that intermittent and continuous clorgyline administration have equal effects on locomotion and mouthing suggests that clorgyline acts early in the process of sensitization, that is, at the stage of triggering the sensitization process.
3. The finding that clorgyline treatment shifts sensitization from locomotion to mouthing suggests that clorgyline exerts its action at a “switch” that selects which motor pathway (locomotion or mouthing) is to be sensitized by repeated injections of quinpirole. Since clorgyline has a high affinity for the MQB site, we suggest that it is the MQB site which acts as this “switch”(7).
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[Neuroscience] |
