Nina M. van Sorge⁽¹⁾, JP Yska⁽²⁾, Hans Blansjaar⁽³⁾, Sandra Driessen⁽⁴⁾, Patricia Schepers⁽⁵⁾, Simon R. Bovenga⁽⁶⁾, A.A. van Sorge^{(7)
(1)(2)(3)(4)(5)(6)}Rijnstate Hospital - ARNHEM. Netherlands
⁽⁷⁾Rijnstate Hospital Arnhem - ARNHEM. Netherlands

	[Pharmacology]	[Orthopedics & Traumatology]

RESULTS

Results of gentamicin release from both Palacos® and Palamed® using the USP XXIV flow-through cell apparatus are presented in Table 1 and Fig.3.

Table 1
DYNAMIC ELUTION OF GENTAMICIN LOADED SURGICAL CEMENT DURING 190 MIN.

Specialties	n	Peak gentamicin level (mg/L); at 10 minutes	Mean gentamicin concentration from 100 minutes (mg/L)	Percentage released
Palamed®	4	93,9 ± 16,2	5,73 ± 0,38	27,1
Palacos®	5	32,0 ± 10,7	1,78 ± 0,05	8,8

Fig.3

In the non-dynamic setting leaching of gentamicin from the bone cement was measured. Results of begin and end points are shown in table 2, whereas leaching characteristics of gentamicin during the whole time period are presented in fig.4.

Table 2
NON-DYNAMIC LEACHING OF GENTAMICIN LOADED SURGICAL CEMENT

Specialties	Gentamicin level after 3 days (mg/L)	Gentamicin level after 190 days (mg/L)	Percentage released after 190 days
Palamed®	1,67 ± 0,13	3,69 ± 0,25	69,9
Palacos®	0,64 ± 0,07	0.67 ± 0,06	13,3

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [FIGURES] [DISCUSSION] [CONCLUSION] [BIBLIOGRAPHY] [PRESENTATION FILE] [Discussion Board]

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	[Pharmacology]	[Orthopedics & Traumatology]

Nina M. van Sorge, JP Yska, Hans Blansjaar, Sandra Driessen, Patricia Schepers, Simon R. Bovenga, A.A. van Sorge
Copyright © 1999-2000. All rights reserved.

Last update: 11/01/00