Poster
# 67
Poster |
|
6th Internet World Congress for Biomedical Sciences |
Nina M. van Sorge(1), JP Yska(2), Hans Blansjaar(3), Sandra Driessen(4), Patricia Schepers(5), Simon R. Bovenga(6), A.A. van Sorge(7)
(1)(2)(3)(4)(5)(6)Rijnstate Hospital - ARNHEM. Netherlands
(7)Rijnstate Hospital Arnhem - ARNHEM. Netherlands
 |
Contact address: |
Nina M. van Sorge Rijnstate Hospital ARNHEM Gld 6814 KX Netherlands N.M.vanSorge@students.pharm.uu.nl |
|
 |
|
|
[Pharmacology] |
[Orthopedics & Traumatology] |
Antibiotic impregnated acrylic bone cement is well accepted in orthopedics. Several brands containing the aminoglycoside antibiotic gentamicin are marketed.
To obtain information on the elution profile of the included antibiotic from the surgical cement, we studied the in vitro release of gentamicin from two marketed brands: Palacos® and Palamed®.
Two experimental arrangements were used to investigated the release of gentamicin from the bone cement.
The elution of gentamicin was tracked both in a non-flowing (non-dynamic time-elapsed elution) setting and by the use of a clearly defined USP XXIV flow-through cell apparatus (#4; pg1945), through which an elution medium was pumped at a constant speed.
Weighed prepared surgical cement samples were placed in the two above mentioned settings and gentamicin release was followed in time. Samples were drawn from the elution medium at pre-determined time intervals. Analysis of the gentamicin concentration in the samples was performed by the TDx-FLx Abbott method.
Palamed® gentamicin concentrations were higher at all time points than from Palacos®. In comparison to Palacos®, peak gentamicin concentrations from Palamed® were approximately three times higher in the dynamic elution setting. In the non-dynamic time-elapsed leaching setting, the elution of gentamicin from Palamed® continued for the measured 190 days in contrast to gentamicin release from Palacos®. The measured final elution concentration of gentamicin at the end of 190 days for Palacos® and Palamed® was 0,67 ± 0,06 and 3,69 ± 0,25 respectively.
|
|
|
|
|
|
[Pharmacology] |
[Orthopedics & Traumatology] |
