Nina M. van Sorge⁽¹⁾, JP Yska⁽²⁾, Hans Blansjaar⁽³⁾, Sandra Driessen⁽⁴⁾, Patricia Schepers⁽⁵⁾, Simon R. Bovenga⁽⁶⁾, A.A. van Sorge^{(7)
(1)(2)(3)(4)(5)(6)}Rijnstate Hospital - ARNHEM. Netherlands
⁽⁷⁾Rijnstate Hospital Arnhem - ARNHEM. Netherlands

	[Pharmacology]	[Orthopedics & Traumatology]

DISCUSSION

Antibiotic impregnated acrylic bone cement (PMMA) beads and surgical cement are well accepted modalities in the treatment and prevention of infection after implantation of endoprostheses.

To obtain information on the elution profile of the included antibiotic from the bone cement, we studied the in vitro release of gentamicin from two marketed brands: Palacos® and Palamed®. Two experimental procedures, a dynamic and non-dynamic setting, were used. Several differences were noted between the two brands. First, the peak concentration of gentamicin was always higher for Palamed®. Second, the total amount of gentamicin released from the bone cement was higher for Palamed®, both in the dynamic and non-dynamic setting. Finally, in the non-dynamic experiment it became clear that leaching of gentamicin from Palacos® reached a steady-state condition, whereas from Palamed® leaching of gentamicin continued during the investigated time-period. This possibly resembles the difference in formulation between the two surgical cements. The clinical significance of the higher elution levels of gentamicin from the Palamed® will be subject of further research ^(4,5).

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [FIGURES] [DISCUSSION] [CONCLUSION] [BIBLIOGRAPHY] [PRESENTATION FILE] [Discussion Board]

---

	[Pharmacology]	[Orthopedics & Traumatology]

Nina M. van Sorge, JP Yska, Hans Blansjaar, Sandra Driessen, Patricia Schepers, Simon R. Bovenga, A.A. van Sorge
Copyright © 1999-2000. All rights reserved.

Last update: 11/01/00