Nina M. van Sorge⁽¹⁾, JP Yska⁽²⁾, Hans Blansjaar⁽³⁾, Sandra Driessen⁽⁴⁾, Patricia Schepers⁽⁵⁾, Simon R. Bovenga⁽⁶⁾, A.A. van Sorge^{(7)
(1)(2)(3)(4)(5)(6)}Rijnstate Hospital - ARNHEM. Netherlands
⁽⁷⁾Rijnstate Hospital Arnhem - ARNHEM. Netherlands

	[Pharmacology]	[Orthopedics & Traumatology]

INTRODUCTION

Antibiotic impregnated acrylic bone cement (PMMA) beads and surgical cement are well accepted modalities in the treatment and prevention of infection after implantation of endoprostheses.

In the 60´s and early ´70´s the complication rate in total hip arthroplasties for postoperative infection was approximately 10%. By introducing strict aseptic techniques in the operating theatre, the introduction of pre- and peri-operative systemic antiobiotic prophylaxis and also the mixing of antibiotics with surgical cement reduced the infection level to less than 1%.

Early reports have appeared on the use and effectiveness of antibiotic impregnated bone cement ^(1,2).

We have undertaken an in vitro comparison of two bone cements loaded with the same antibiotic, gentamicin by use of two experimental settings; dynamic and non-dynamic time-elapsed leaching ⁽³⁾.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [FIGURES] [DISCUSSION] [CONCLUSION] [BIBLIOGRAPHY] [PRESENTATION FILE] [Discussion Board]

---

	[Pharmacology]	[Orthopedics & Traumatology]

Nina M. van Sorge, JP Yska, Hans Blansjaar, Sandra Driessen, Patricia Schepers, Simon R. Bovenga, A.A. van Sorge
Copyright © 1999-2000. All rights reserved.

Last update: 11/01/00