Francisca Mulero⁽¹⁾, J.A. Ruiz-Ros⁽²⁾, F. Martinez-Corbalan⁽³⁾, F. Picó⁽⁴⁾, J.A. Nuño de la Rosa^{(5)
(1)(2)(5)}Hospital Universitario Virgen de la Arrixaca - San Miguel de Salinas. Spain
⁽³⁾⁽⁴⁾Servicio de Medicina Nuclear. Hospital Universitario Virgen de la Arrixaca - Murcia. Spain

	[Genetics & Bioinformatics]	[Radiology & Nuclear Medicine]

MATERIAL & METHODS

24 syndrome x patients (20 women and 4 men, 50 to 65 year old) were included in the study. Syndrome X diagnosis was based on the following criteria: (i) presence of typical exertional angina, (ii) ST-segment depression on exercise test and (iii) presence of angiographically normal coronary arteries. Patients presenting coronary artery spasm, cardiomyopathy, congestive heart failure, valvular heart disease (including mitral valve prolapse), systemic hypertension, left ventricular hypertrophy or conduction abnormalities, were excluded.

SPET studies with 111MBq Tl-201 injected at peak of exercise were carried out and redistribution images were obtained 4 h after the injection. Exercise was performed according to the standard graded treadmill test (Bruce protocol). The exercise test was limited by: (i) symptom appearance, (ii) 4mm ST depression, (iii) malignant arrhythmia or (iv) exercise induced hypotension (>10 mmHg drop between exercise stages). Less than 85% of the maximal predicted heart rate, was considered as "suboptimal effort".

Quantitation in the Tl-201 myocardial studies was done according to the Cedars Sinai protocol.

Thallium uptake was quantified in Syndrome X patients both during exercise and in resting periods and the data obtained was then compared to that from obtained healthy control individuals. Male and female patients were compared with same-gender control individuals. Washout values were calculated applying the formula:

Exercise levels, number of total doses administered and time between 2 SPET acquisitions (exercise and rest) were similar in patients showing Syndrome X and in the control group.

Data were procesed following a descriptive method and the mean and standard deviation were also calculated. To asses the statistical significance of the data a modified Student´s t test was also performed. Which included a variant of comparison of means with a theoretical mean, after checking that variables had a normal distribution. A value of p < 0.05 was considered statistically significant

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [FIGURES] [DISCUSSION] [CONCLUSION] [Discussion Board]

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	[Genetics & Bioinformatics]	[Radiology & Nuclear Medicine]

Francisca Mulero, J.A. Ruiz-Ros, F. Martinez-Corbalan, F. Picó, J.A. Nuño de la Rosa
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Last update: 16/01/00