Poster
# 68
Poster |
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6th Internet World Congress for Biomedical Sciences |
Francisca Mulero(1), J.A. Ruiz-Ros(2), F. Martinez-Corbalan(3), F. Picó(4), J.A. Nuño de la Rosa(5)
(1)(2)(5)Hospital Universitario Virgen de la Arrixaca - San Miguel de Salinas. Spain
(3)(4)Servicio de Medicina Nuclear. Hospital Universitario Virgen de la Arrixaca - Murcia. Spain
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[Genetics & Bioinformatics] |
[Radiology & Nuclear Medicine] |
Syndrome X is a pathology of unknown etiology, usually associated with chest pain in patients showing typical exertional angina and reduction of S-T upon exercise tests. These patients also show normal coronary arteries. The alterations that lead to development of Syndrome X are still unknown. However, microvascular angina and coronary reserve flow reduction have been proposed as possible causes.
Studies with Thallium 201 show that approximately 20% of Syndrome X patients show a reversible reduction in blood flow reserve. This reduction in blood flow reserve may occur locally or have a wide distribution, and may affect Thallium uptake kinetics.
Myocardial perfusion reserve is also reduced in a substantial number of patients presenting chest pain and angiographically normal coronary arteries. In this regard, PET studies showed an elevated resting myocardial perfusion in Syndrome X patients. This defect, rather than a global reduction in the maximum coronary flow, seems to be the most likely cause for the limited coronary flow reserve that Syndrome X patients show.
The aim of the current study is to evaluate the possible use of quantitative analysis of Thallium 201 washouts, in combination with polar maps and slice studies, as a complementary test to study the perfusion alterations shown by Syndrome X patients.
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[Genetics & Bioinformatics] |
[Radiology & Nuclear Medicine] |
