Bettina Bert⁽¹⁾, Andre Rex⁽²⁾, Heidrun Fink^(3)
(1)Institute of Pharmacology and Toxicology. Humboldt-University Berlin, Charite - Berlin. Germany
⁽²⁾Institute of Pharmacology and Toxicology. VB Vterinary medicine, Free University - Berlin. Germany
⁽³⁾Institute of Pharmacology and Toxicology. School of Veterinary Medicine, Free University Berlin - Berlin. Germany

	[Neuroscience]	[Pharmacology]

RESULTS

Elevated plus maze test

A. Saline treated animals

fig. 1

The Harlan-Wistar rats showed a less anxious behaviour in the elevated plus maze test than the Harlan-Fischer and the FIHV-Wistar rats. The Harlan-Wistar rats spent significantly more time in the open arms and showed a higher number of head dips than the two other groups. They also entered the open arms more frequently.

B. Effect of diazepam

fig. 2

This parameter shows representatively that diazepam achieved an axiolytic effect already at a dose of 0.5 mg/kg in the more anxious Harlan-Fischer rats. Whereas, in the less anxious Harlan-Wistar rats diazepam had no anxiolytic effect at a dose of 4.0 mg/kg. In the FIHV-Wistar rats there was a tendency for an anxiolytic effect.

Plasma concentration

fig. 3

The concentrations of diazepam and the three metabolites are significantly increased in the more anxious Harlan-Fischer rats in comparison to both stocks of Wistar rats. Whereas, there is no difference between the two stocks of Wistar rats. Additionally, the Harlan-Fischer rats seem to metabolize diazepam to nordiazepam and temazepam to the same extent.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]

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	[Neuroscience]	[Pharmacology]

Bettina Bert, Andre Rex, Heidrun Fink
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Last update: 6/01/00