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6th Internet World Congress for Biomedical Sciences

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DIFFERENT ANXIOLYTIC EFFECTS OF DIAZEPAM IN FISCHER 344 RATS AND TWO STOCKS OF WISTAR RATS IN THE ELEVATED PLUS MAZE

Bettina Bert(1), Andre Rex(2), Heidrun Fink(3)
(1)Institute of Pharmacology and Toxicology. Humboldt-University Berlin, Charite - Berlin. Germany
(2)Institute of Pharmacology and Toxicology. VB Vterinary medicine, Free University - Berlin. Germany
(3)Institute of Pharmacology and Toxicology. School of Veterinary Medicine, Free University Berlin - Berlin. Germany

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
ABSTRACT Previous: The Neurophysiology of Hypnosis: Hypnosis as a State of Selective Attention and Disattention. Previous: PREPARATION OF A 5% FLURBIPROFEN HYDROGEL: Pharmaceutical aspects MATERIAL & METHODS
[Neuroscience]
Next: Neural Networks for the Detection of EEG Arousal During Sleep.		 [Pharmacology]
Next: Determination of the Protection Level for Post Chemotherapy Emesis with a Multilayer Perceptron.

INTRODUCTION

Studies about anxiety-related behaviour have shown different and sometimes contradictory results even when identical animal models of anxiety were used (1).

Rat strains kept under identical environmental conditions show distinct baseline levels of anxiety related behaviour (2).

It is reported in literature that strain differences might contribute to different effects to ‘anxiolytic’ or ‘anxiogenic’ drugs (3).

In this study Fischer 344 and Wistar rats were examined after intraperitoneally application of diazepam in an animal model of anxiety.

Additionally, the plasma concentrations of diazepam and three of its metabolites were measured.

It is an aim in future investigations to determine the changes of the behaviour of genetically manipulated animals.Therefore, the knowledge of the behaviour of different rat strains and stocks is indispensable.

Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
ABSTRACT Previous: The Neurophysiology of Hypnosis: Hypnosis as a State of Selective Attention and Disattention. Previous: PREPARATION OF A 5% FLURBIPROFEN HYDROGEL: Pharmaceutical aspects MATERIAL & METHODS
[Neuroscience]
Next: Neural Networks for the Detection of EEG Arousal During Sleep.		 [Pharmacology]
Next: Determination of the Protection Level for Post Chemotherapy Emesis with a Multilayer Perceptron.
Bettina Bert, Andre Rex, Heidrun Fink
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