Bettina Bert⁽¹⁾, Andre Rex⁽²⁾, Heidrun Fink^(3)
(1)Institute of Pharmacology and Toxicology. Humboldt-University Berlin, Charite - Berlin. Germany
⁽²⁾Institute of Pharmacology and Toxicology. VB Vterinary medicine, Free University - Berlin. Germany
⁽³⁾Institute of Pharmacology and Toxicology. School of Veterinary Medicine, Free University Berlin - Berlin. Germany

	[Neuroscience]	[Pharmacology]

CONCLUSIONS

In the elevated plus maze test Harlan-Winkelman rats showed a less anxious behaviour than the Harlan-Fischer and the FIHV-Wistar rats.

Additionally, diazepam achieved a more pronounced anxiolytic effect in the more anxious Harlan-Fischer rats compared to the less anxious Harlan-Wistar rats (ceiling effect?).

There is also a big difference in the kinetics of diazepam between the Harlan-Fischer rats and the two stocks of Wistar rats (different liver enzymes?).

These results indicate that there are distinct strain and stock differences in the anxiety related behaviour, in the response to, and, in the kinetics of diazepam.

These differences should be taken into consideration for the interpretation of the test results.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]

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	[Neuroscience]	[Pharmacology]

Bettina Bert, Andre Rex, Heidrun Fink
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Last update: 6/01/00