Poster | 6th Internet World Congress for Biomedical Sciences |
Eiichi Yagi(1)
(1)Akita Red Cross Hospital - Akita. Japan
[Dermatology] |
[Health Informatics] |
Making of time series data (making of 700-2000 vectors )
1)Distance between cells
a. Cell interval is sought when the marker is arranged in concentric circular from the center of the image.
b. All combinations of distance between all 2 cells are sought, and the cell number that two cells enter in the limited interval divided with equal length is counted.
c. Cells are plotted with a certain width lengthwise, and arranged in order from near side. Distance of all pairs is measured.
2)Size of nucleus, A length / area of circumference, Concentration difference of nucleus
Value is put away in order of coordinate, and nucleus is extracted by order of 1).
Specimens to examine histopathologically
normal skin, seborrheic keratosis 6 cases, actinic keratosis 8 cases, Bowen´s disease 6 cases, basal cell carcinoma 5 cases, squamous cell carcinoma 4 cases, Paget´s disease 4 cases, dermatofibroma 3 cases, hemangioma 4 cases, pigmented nevus 6 cases
Distance between cells | Size of nucleus | A length / area of circumference | Concentration difference of nucleus | |
normal skin | 6.1 | 3.31 | 6.0 | 5.92 |
seborrheic keratosis | 5.1 | 4.3 | 5.82 | 5.34 |
actinic keratosis | 5.0 | 2.61 | 6.4 | 4.2 |
Bowen disease | 5.0 | 1.42 | 6.75 | 4.02 |
squamous cell carcinoma | 4.9 | 0.85 | 7.87 | 6.15 |
basal cell cancer | 5.2 | 1.35 | 6.67 | 1.74 |
Paget disease | 4.6 | 2.65 | 7.4 | 3.1 |
dermatofibroma | 4.84 | 2.6 | 7.68 | 6.88 |
hemangioma | 3.6 | 2.22 | 6.8 | 7.9 |
pigmented nevus | 6.05 | 3.0 | 6.16 | 6.2 |
Simple fractal dimension of the circumference in virtual tumor | |
Probability of the cell size change at one division of cell (0 to 0.9) |
In order to bring the character of virtual tumor close to the real tumor the coincidence of these dimensions is necessary. Coincidence within a small range may be possible, although a lot of computation process is necessary even in such accordance. If various kinds of algorithms (Genetic Algorithms, serious inquiry method etc.) are used and applied appropriately to choose the functions and coefficients, the examination of character with spreading of cells may be possible.
[Dermatology] |
[Health Informatics] |