Eiichi Yagi^(1)
(1)Akita Red Cross Hospital - Akita. Japan

	[Dermatology]	[Health Informatics]

MATERIALS & METHODS

Hardware and soft ware: PC-AT compatible computer AMD K2-450 (RAM 256MB)
video RAM 16M, Windows 98,
Visual Basic 5.0 (Microsoft)
( All programs were written by Eiichi Yagi MD)

Virtual cells multiply as a kind of celler automaton algorithm. (Fig. 1)
1- distance of all cells from initial the dividing cell is measured.
2- new cell keeps 1dot from the dividing cell.
3- extract the nearest cell that overlapped with the dividing cell.
4- these cells are supposed to be a ball, then the direction of the move is calculated.
5- the position of cells is corrected not to be overlapped.
6- the cells that overlapped with this cell are computed, and process 4 is done with all cells that are extracted.
7- return to process 2, and the work has been done until all cells are completely divided.
The form of virtual epidermis changes with regulating the selection probability, the mitosis probability, the radius and division direction.

Refer code for execution

Figure 1

Celler automaton
This is an automatic proliferation model devised by Neumann. Unit automaton that is arranged on the plane like a cell changes its internal state only according to the condition of self and its vicinity, so the movement of all units automatically determines the movement of the whole system.

Setting of the parameter and the function of the individual virtual cell
X-coordinate, Y-coordinate, radius, a longer axis, a division tendency, display of division direction, on basal layer or not, Xb of cell (growth factor), Yb of cell (inhibitory growth factor), a history of the successive division which depended on concentration, initial width, initial height, cell number, basal layer - x,y, granular layer - x,y, distance to the horny layer, division frequency, a size difference of a cell in division, division angle after division, division frequency with the same range, division arrest after successive division, elasticity on the horny layer, elimination frequency on the horny layer, elimination frequency on theh horny layer (altitude is not related), How many horny layers is torn off?, only basal cell is divided, probability that high concentration induced the division on the basal layer, ratio of diffusion rate of Xb and Yb, increse of Xb substance synthesis, decrease of Xb substance synthesis, division direction on the basal layer - level, verticality, angle
Random control for each parameter -- another 10-15 parameters are required.
Functions for the internal processing in proliferation -- another 10-15 functions are required.

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Application of Turing method 1)
Two substances of P and Q are supposed. P promotes the synthesis of P and Q with the concentration of P. In the location where the concentration of P is high, the synthesis of Q and P is high. Q is supposed to be inhibitor of P synthesis. If concentration of Q is high, the synthesis of P is repressed. P and Q spread through circumference by the diffusion, and the diffusion velocity of Q is assumed to be larger than the diffusion velocity of P. This is Turing method. When the parameter of the reaction and diffusion are selected properly, the condition of system is stabilized in the repetition pattern of wavy shape, even if it begins from any kind of initial condition. Method of Turing is embedding in virtual cell. When substance X and Y spread, the probability of division is set to be influenced by this factor (X, Y). The shift of the cell growth position and the alteration of rete ridge were examined. When the virtual growth factor (virtual inflammation substance) is distributed to individual cells with various kinds of probability in a certain range, the dilatation of multiplied cells, which means the form of exanthema, was examined.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIALS & METHODS] [RESULTS] [EXAMINATION OF THE DIMENSION ON HISTOPATHOLOGY OF SKIN DISEASES] [CONCLUSION] [REFERENCE] [Discussion Board]

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	[Dermatology]	[Health Informatics]

Eiichi Yagi
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Last update: 30/1/2000