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6th Internet World Congress for Biomedical Sciences

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In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.

María Dolores Mayas-Torres(1), José Manuel Martínez-Martos(2), María Jesús Ramírez-Expósito(3), María Jesús García-López(4), Isabel Prieto-Gómez(5), Garbiñe Arechaga-Maza(6), Manuel Ramírez-Sánchez(7)
(1)(2)(4)(5)(6)(7)Unit of Physiology. University of Jaén - Jaén. Spain
(3)Unit of Physiology. University of Jaen - Jaén. Spain

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [DISCUSSION AND CONCLUSIONS] [BIBLIOGRAPHY] [Discussion Board]
ABSTRACT Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. MATERIAL & METHODS
[Endocrinology]
Next: Differential effects of exogenous oleic and linoleic fatty acids and cholesterol on aminopeptidase activities in rat astrocytes in primary culture.		 [Neuroscience]
Next: Utility of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay to measure mitochondrial activity in K+- and ATP- stimulated rodent cortex synaptosomes.		 [Pharmacology]
Next: Reduced energy consumption by dexamethasone in the mouse heart.		 [Physiology]
Next: Utility of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay to measure mitochondrial activity in K+- and ATP- stimulated rodent cortex synaptosomes.		 [Toxicology]
Next: DISTRIBUTION OF CADMIUM AND ITS EFFECTS ON THE ORGAN CONCENTRATIONS OF RETINOIDS AND BETA-CAROTENE

INTRODUCTION

Pyroglutamyl aminopeptidase (pGluAP) can be classified as an omega-peptidase which removes pyroglutamyl N-terminal residues from peptides, proteins and arylamidase derivatives in a highly selective manner (1,2). The activity of this enzyme is thought to be involved in the regulation of several physiological mechanisms on the central nervous system (CNS). pGluAP can modulate various susceptible endogenous substrates such as thyrotropin-releasing hormone (TRH). It is well known that TRH plays an important role in the modulation of the behavioral changes induced by ethanol and others drugs. The aim of this work was to study the in vitro effects of ethanol (25, 50 and 100 mM) on the pGluAP activity and its ability for modulating the TRH.

Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [DISCUSSION AND CONCLUSIONS] [BIBLIOGRAPHY] [Discussion Board]
ABSTRACT Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. Previous: Effects of ethanol on aminopeptidase A in cortical synaptosomes. MATERIAL & METHODS
[Endocrinology]
Next: Differential effects of exogenous oleic and linoleic fatty acids and cholesterol on aminopeptidase activities in rat astrocytes in primary culture.		 [Neuroscience]
Next: Utility of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay to measure mitochondrial activity in K+- and ATP- stimulated rodent cortex synaptosomes.		 [Pharmacology]
Next: Reduced energy consumption by dexamethasone in the mouse heart.		 [Physiology]
Next: Utility of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay to measure mitochondrial activity in K+- and ATP- stimulated rodent cortex synaptosomes.		 [Toxicology]
Next: DISTRIBUTION OF CADMIUM AND ITS EFFECTS ON THE ORGAN CONCENTRATIONS OF RETINOIDS AND BETA-CAROTENE
María Dolores Mayas-Torres, José Manuel Martínez-Martos, María Jesús Ramírez-Expósito, María Jesús García-López, Isabel Prieto-Gómez, Garbiñe Arechaga-Maza, Manuel Ramírez-Sánchez
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