Satoshi Iwabuchi⁽¹⁾, Yasushi Sakai⁽²⁾, Hitoshi Kimura⁽³⁾, Shinya Yoshii⁽⁴⁾, Tetsuya Yokouchi⁽⁵⁾, Morikazu Ueda⁽⁶⁾, Hirotsugu Samejima^{(7)
(1)(3)(4)(5)(6)(7)}Department of Neurosurgery. Toho University - Tokyo. Japan
⁽²⁾Department of Physiology. Showa University College of Medical Sciences - Japan

Introduction

Cerebral vasospasm is a major cause of morbidity and mortality in patients who have suffered an aneurysmal SAH ^(1,2,3). Although the pathogenesis of cerebral vasospasm is still unclear, it is generally considered that the blood component or erythrocyte products in bloody CSF, such as oxyhemoglobin, are closely related to cerebral vasospasm ^(4,5).

It has been established that adenosine 5'-triphosphate (ATP) regulates smooth muscle tone by binding to P₂ purinoceptors ^(6,7). ATP is abundant in human erythrocytes as well as in other animal red blood cells ⁽⁸⁾. Therefore, it has been reported that ATP may contribute to the vasoconstriction that occurs in vasospasm ^(9,10,11).

The purposes of the present study were to determine whether CSF obtained from patients with SAH on successive days following the hemorrhage causes contraction of cerebral smooth-muscle cells, and to investigate intracellular Ca²⁺ mobilization in smooth-muscle cells during contraction. Furthermore, we examined the involvement of nucleotides in CSF-induced contraction of smooth-muscle cells.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [Introduction] [Materials & Methods] [Results] [Tables & Figures] [Discussion & Conclusion] [References] [Discussion Board]

---

Satoshi Iwabuchi, Yasushi Sakai, Hitoshi Kimura, Shinya Yoshii, Tetsuya Yokouchi, Morikazu Ueda, Hirotsugu Samejima
Copyright © 1999-2000. All rights reserved.

Last update: 19/01/00