Poster
# 97
Poster |
|
6th Internet World Congress for Biomedical Sciences |
Alberto Pizarro Gallardo(1)
(1)Facultad de Medicina U.A.N. - Tepic. Mexico
|
 [Obstetrics & Gynecology] |
|
|
|
[Oncology] |
[Pathology] |
Uterine sarcomas comprise less than 1 % of gynecologic malignancies nd 2-5 % of all uterine malignancies.(1-2)
The term “ Müllerian Adenosarcoma of the uterus” (MAU) was defined in 1974 by Clement and Scully (3).
The tumor arise primarily of the Müllerian mesodermal tissue from endometrial epithelium.
MAU usually occurs in older women, and vaginal bleeding in the most common presenting complaint. The lesion grows as a polypoid mass within the endometrial cavity, and composed of histologically benign glands within a sarcomatous stroma. (3-10)
These tumors generally have a low grade of malignancy in contrast to the other more aggresive uterine sarcomas and are often followed by local recurrence, but only rarely by metastases.
One etiologic risk factor is prior pelvic radiation.
MAU tumors are classified into homologous and heterologous tumors, depending on the characteristics of the mesenchymal elements. While mesenchymal elements are composed of nonspecific spindle-shaped sarcomatous cells in the homologous tumors; sarcomatous cells show special differentiation such as cartilage, osteoid and striated muscle in the heterologous tumors. (10)
The ultrastructure of MAU is : The epithelial cells in the glands are lined by simple o stratified columnar cells. The cytoplasm contained numerous mitochondria, glycogen, rough endoplasmic reticulum (rer), Golgu apparatus. Nucleoli are prominent, desmosomes are abundant, microvilli were numerous. Cilia and basal lamina in all cases. (10-13)
Mesenchymal cells. The cells were moderately pleomorphic and spindle shaped separated by bundles of irregularly arrenged collagen. The cells was fusiform nuclei and prominent often multiple, nucleoli, cellular cytoplasm was scanty. Cilia and microvilli is absent. Basal lamina is absent.
a. Immature stromal cells have cytoplasm scanty, with few mitochondrias and scattered rough endoplasmic reticulum (rer), the nucleus tended to be round or oval with little chromatin clumping.
b. Mature stromal cells have abundant cytoplasm, with prominent rer, and a well developed, Golgi apparatus, mitochondria present. Cytoplasm projections resembling pseudopods, and often containing large lipid inclussions.. The nuclei were irregular in shaped often with prominent lobulations.
Our objetives were to identify the ultrastructural differentiation between epithelial and sarcomatous cells of MAU.
In this report, we describe the ultrastructural features of seven MAU.
|
|
[Obstetrics & Gynecology] |
|
|
|
|
[Oncology] |
[Pathology] |
