Margot M.S. Naaijkens⁽¹⁾, A.A. van Sorge^(2)
(1)Rijnstate Hospital - ARNHEM. Netherlands
⁽²⁾Rijnstate Hospital Arnhem - ARNHEM. Netherlands

	[Pharmacology]	[Dermatology]

DISCUSSION

Meglumine is essential to obtain a clear and transparent 5% flurbiprofen hydrogel. The optimal pH is established at 6.8. At this pH the flurbiprofen is still soluble and the conservative capacity of Kathon CG® is preserved. The consistency is still a problem. At 1.8% hydroxyethylcellulose it is median and the cosmetic appearance is good. At 2% the consistency is good but the cosmetic value becomes less. With dermal application of the clear, transparent 2%- gel it becomes cloudy and sticky, while using the 1.8%-gel this does not happen and the gel soaks into the skin.

Clotting during preparation of the 2% hydrogel by hand can be overcome by use of a rotor-statormixer.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [DISCUSSION] [CONCLUSIONS] [BIBLIOGRAPHY] [PRESENTATION FILE] [Discussion Board]

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	[Pharmacology]	[Dermatology]

Margot M.S. Naaijkens, A.A. van Sorge
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Last update: 13/01/00