Poster
# 38
Poster |
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6th Internet World Congress for Biomedical Sciences |
Peter Massanyi(1), Laszlo Bardos(2), Robert Toman(3), Svatoslav Hluchy(4), Jaroslav Kovacik(5), Norbert Lukac(6)
(1)(3)(4)(6)Slovak Agricultural University - Nitra. Slovakia
(2)University of Agricultural Sciences - Godollo. Hungary
(5)Slovak University of Agriculture - Nitra. Slovakia
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[Toxicology] |
[Reproduction Sciences] |
Concern about the constantly increasing environmental levels of heavy metals has stimulated interest in the study of toxic substances on life systems. Cadmium, one of these substances is a toxic, environmental pollutant that serves no biological function, and is therefore totally unwanted. Cadmium is chemically similar to zinc and occurs naturally with zinc and lead in sulfide ores. Some cadmium has been found in all natural materials that have been analyzed. High concentrations in air, water and soil are, however, commonly associated with industrial emission sources, particularly non-ferrous mining and metal refining (4).
Exposure to cadmium, via air and food, leads to renal tubular dysfunction. This is primarily a reabsorption defect in the proximal tubules and the critical effect of cadmium (4,5,13,14). There are also various effects on reproduction, causing follicular atresia (10), edematization of uterus (12) as well as degenerative alterations in testes (18). Cadmium mainly accumulates in kidneys and liver (4,9,15,16).
It is estabilished that vitamin A and cadmium are preferentially accumulated in the liver in high concentrations and that the metabolism of the vitamin is controlled in the liver (6). This suggests the possibility of an effect of cadmium on vitamin A metabolism.
The aim of our work was to investigate the distribution of cadmium (kidney, liver, muscle, spleen, testes, ovary) after an intraperitoneal (i.p.) administration and determine concentration of retinyl palmitate, retinol and ß-carotene in liver, kindey and testes in mice.
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[Toxicology] |
[Reproduction Sciences] |
