Sergej P. Osinsky, M.D.,⁽¹⁾, I Levitin⁽²⁾, L Bubnovskaya⁽³⁾, A Sigan⁽⁴⁾, I. Ganusevich⁽⁵⁾, V. Michailenko⁽⁶⁾, T. Kovelskaya^{(7)
(1)(2)(3)(4)(5)(6)(7)}Inst. exp. Pathol. Oncol. Radiobiol. - Kiev . Ukraine

	[Biophysics]	[Oncology]

INTRODUCTION

The interactions of metal complexes with biological systems, which is the field of biocoordination chemistry, is receiving increasing interest. Some authors have presented the first results of their studies concerning the biological activity of organometallic compounds, in particular several alkyne-cobalt carbonyl complexes which inhibited the growth of human melanoma and lung carcinoma cell lines ⁽¹⁾.

It is relevant to notice that cobalt compounds have been under the increased interest as potential radiosensitizers during the last 10 years. It was observed that cobalt(III) complexes have shown specific hypoxic radiosensitization and thermosensitization as well as antitumor activity in vivo ^(2-4). Some current observations have suggested that further investigations with cobalt-containing complexes are warranted ^(5,6).

It was supposed that cobalt compounds would be of particular interest because of coordination capacity of the metal center and their ability to catalyze redox processes involving (di)oxygen and active oxygen species as well as biogenic substrates. In this connection, we take notice of Dori & Gershon patent ⁽⁷⁾ claiming antitumor action of cobalt(III) complexes with tetradentate Schiff bases derived from aliphatic beta-diketones and diamines, which was observed in the case of ascite form of Erlich carcinoma. Carrying out a more thorough biomedical examination of the complexes in question, it was found in our experiments that above a moderate conventional antitumor activity, similar to that described in the just mentioned patent, they exhibit a pronounced modifying effect sharply enhancing the action of radiation and local microwave hyperthermia ^(8,9). Furthemore, the complexes alone are found to display a significant antimetastatic activity exceeding that of platidiam and cyclophosphamid ^(8,9). It was then succeeded in our experiments the synthesizing complexes superior to the known ones in their modifying and antitumor activities.

This study was aimed to perform the biomedical examination of new synthesized "inorganic" cobalt(III) complexes in experiments in vivo.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [DISCUSSION] [CONCLUSIONS] [REFERENCES] [Discussion Board]

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	[Biophysics]	[Oncology]

Sergej P. Osinsky, M.D.,, I Levitin, L Bubnovskaya, A Sigan, I. Ganusevich, V. Michailenko, T. Kovelskaya
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Last update: 15/01/00