Sergej P. Osinsky, M.D.,⁽¹⁾, I Levitin⁽²⁾, L Bubnovskaya⁽³⁾, A Sigan⁽⁴⁾, I. Ganusevich⁽⁵⁾, V. Michailenko⁽⁶⁾, T. Kovelskaya^{(7)
(1)(2)(3)(4)(5)(6)(7)}Inst. exp. Pathol. Oncol. Radiobiol. - Kiev . Ukraine

Contact address:

Sergej P. Osinsky, M.D., Inst. exp. Pathol. Oncol. Radiobiol. Natl. Acad. Sci. of Ukraine Vasilkovskaya Str. 45 Kiev 03022 Ukraine osion@onconet.kiev.ua

	[Biophysics]	[Oncology]

ABSTRACT

Objectives: to test the biological activity of "inorganic" cobalt(III) complexes with tetradentate Schiff bases and different biogenic nitrous bases or an analogous synthetic ligands.

Materials&Methods: some cobalt(III) complexes with basic structure [Co(acac2en)(NH3)2]Cl that are containing no metal-carbon bond, and their analogs with different ligands were tested in vivo. Here they are exemplified by AC-11, AC-30 and AC-40 complexes. Transplanted rodent tumors [Guerin carcinoma, Walker-256 carcinoma, Lewis lung carcinoma (3LL), melanoma B16, adenocarcinoma Ca755] were used in this study. Complexes were given i.p. or i.v.. Local hyperthermia (LHT) (1 h, 43 or 410C) was performed by microwave unit. The tumors were irradiated by 190 kV X-rays at 1.23 Gy/min (RT). Tumor-s response to treatment was estimated by standard methods.

Results: all cobalt complexes of AC-series have been shown to display substantial anticancer, in particular antimetastatic activity: 1) primary tumor inhibition: Guerin carcinoma by 72 (AC-11), 74 (AC-40) and 74% (AC-30), Ca755 - by 76 (AC-11), 77 (AC-40) and 79% (AC-30); B-16 - by 50 (AC-11), 57 (AC-40) and 65% (AC-30); 2) metastases inhibition: 3LL - by 67 (metastases number) and 90% (metastases volume) (AC-11) and 84 and 99% (AC-30); B16 - by 75 and 76% (AC-11) and 71 and 99% (AC-30). Moreover, these complexes have enhanced the antitumor effect of LHT (Tumor Growth Delay after "410C+AC" was the same with those after 430C alone) as well as RT (dose modifying factor = 2.0). Some other analogs of above mentioned complexes with other biogenic bases are under design and investigation.

Conclusion: our results have indicated that "inorganic" cobalt complexes can be regarded as prospective selective anticancer agents with significant modifying activity.

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Keywords: radiotherapy - oncology - inorganic cobalt - Schiff bases -

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Discussion Board

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[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [DISCUSSION] [CONCLUSIONS] [REFERENCES] [Discussion Board]

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	[Biophysics]	[Oncology]

Sergej P. Osinsky, M.D.,, I Levitin, L Bubnovskaya, A Sigan, I. Ganusevich, V. Michailenko, T. Kovelskaya
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Last update: 15/01/00