6th Internet World Congress for Biomedical Sciences February 14-25, 2000
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SESSION I. Neuroscience, Neurology, Neurosurgery, 
Psychiatry

Testing the dopamine hypothesis of Attention-Deficit Hyperactivity Disorder (ADHD): hypo or hyper?

Chair: Dr. Adolfo Gustavo Sadile - II University of Naples. - agsadile@tin.it Italy
Co-Chair: Dr. Joseph A. Sergeant - Free Univ.Amsterdam - JA.Sergeant@psy.vu.nl Netherlands
Co-Chair: Dr. Mary Solanto - - mary_solanto-gardner@mssm.edu United States

[Discussion]

On-line Session: February 18th, 5-7 pm GMT

HUMAN STUDIES

(113) Brain Imaging of the Dopamine Transporter in ADHD.

Professor Bertha Madras - Harvard Medical School - bertha_madras@hms.harvard.edu United States
Dr. Gregory Miller - Harvard Medical School - bertha_madras@hms.harvard.edu United States
Dr. Richard De La Garza - Harvard Medical School - bertha_madras@hms.harvard.edu United States
Dr. Darin D Dougherty - Harvard Medical School - bertha_madras@hms.harvard.edu United States
Dr. Ali A Bonab - Harvard Medical School - bertha_madras@hms.harvard.edu United States
Dr. Thomas J Spencer - Harvard Medical School - bertha_madras@hms.harvard.edu United States
Dr. Scott L Rauch - Harvard Medical School - bertha_madras@hms.harvard.edu United States
Dr. Alan J Fischman - Harvard Medical School - bertha_madras@hms.harvard.edu United States

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(126) Pharmacokinetic and Pharmacodynamic Properties of Stimulants: Implications for the Design of New Treatments for ADHD

Dr. J.M. Swanson - University of California at Irvine - jmswanso@uci.edu United States
Dr. N. Volkow - Brookhaven National Laboratories - jmswanso@uci.edu United States

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(125) Dopamine Dysregulation in AD/HD: Integrating Clinical and Basic Science Research.

Dr. Mary Solanto - - mary_solanto-gardner@mssm.edu United States

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(116) DA may be ´hyper´ with respect to noradrenaline (NA) metabolism, but ´hypo´ with respect to serotonin (5-HT) metabolism in ADHD children

Prof Robert Oades - University of Essen - oades@uni-essen.de Germany

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(124) Hypothesis:
Methylphenidate elevates resting dopamine which lowers impulse-triggered release of dopamine

Dr. Philip Seeman - University of Toronto - philip.seeman@utoronto.ca Canada
Professor Bertha Madras - Harvard Medical School - bertha_madras@hms.harvard.edu United States

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(114) Psychiatric Pharmacogenetics: Emerging Insights from Studies of Clozapine Response.

Mr. Mario Masellis - Centre for Addiction and Mental Health - mario.masellis@utoronto.ca Canada
Mr. Vince Basile - Centre for Addiction and Mental Health - vincebasile@ica.net Canada
Dr. James Kennedy - Centre for Addiction and Mental Health - james_kennedy@camh.net Canada
Dr. Fabio Macciardi - Centre for Addiction and Mental Health - fabio_macciardi@camh.net Canada

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(128) Adult ADHD: an association study with the Dopamine D3 Receptor Gene.

Dr. Pierandrea Muglia - University of Toronto - Pierandrea_Muglia@camh.net Canada
Dr. Umesh Jain - University of Toronto - Umesh_Jain@camh.net Canada
Dr. James Kennedy - Centre for Addiction and Mental Health - james_kennedy@camh.net Canada

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(123) The Neuropsychology of Attention-Deficit/Hyperactivity Disorder (AD/HD) in a Hypodopaminergic System.

Dr. Terje Sagvolden - University of Oslo - terje.sagvolden@basalmed.uio.no Norway
Ms. Heidi Aase - University of Oslo - Heidi.Aase@basalmed.uio.no Norway
Mr. Espen Borgå Johansen - University of Oslo - E.B.Johansen@basalmed.uio.no Norway

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"IN VIVO" ANIMAL STUDIES

(111) The contribution of comparative studies in inbred strains of mice to the understanding of the hyperactive phenotype.

Dr. S. Cabib - Univ. of Rome La Sapienza - cabib@ipsifar.rm.cnr.it Italy

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(109) Adolescent mice show peculiar responses to acute and chronic stress as well as to d-amphetamine administration

Dr. W. Adriani - Istituto Superiore di Sanità - laviola@iss.it Italy
Dr. F. Cirulli - Istituto Superiore di Sanità - laviola@iss.it Italy
Dr. G. Laviola - Istituto Superiore di Sanità - laviola@iss.it Italy

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(112) Inhibition Of Neuronal Nitric Oxide Synthesis By 7-Nitroindazole Reduces Hyperactivity And Increases Non-Selective Attention In The Naples High Excitability Rat Model Of Adhd: An Evidence In Favour Of An Hyperfunctioning Dopamine System.

Dr. G. Grammatikopoulos - II University of Naples - agsadile@tin.it Italy
Dr. M. Pignatelli di Spinazzola - II University of Naples - agsadile@tin.it Italy
Dr. A. Fresiello - II University of Naples - agsadile@tin.it Italy
Dr. U.A. Gironi Carnevale - II University of Naples - agsadile@tin.it Italy
Dr. Adolfo Gustavo Sadile - II University of Naples. - agsadile@tin.it Italy

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(127) Dopamine output from noradrenergic neurons in the prefrontal cortex: regulation by alpha-2-adrenoceptors.

Dr Alessandro Zuddas - University of Cagliari - azuddas@unica.it Italy
Dr. Paola Devoto - University of Cagliari - pdevoto@unica.it Italy
Dr. Giovanna Flore - University of Cagliari - azuddas@unica.it Italy
Dr. Rosalba Satta - University of Cagliari - azuddas@unica.it Italy
Dr. GianLuigi Gessa - University of Cagliari - lgessa@unica.it Italy

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(122) Impaired Metabolic Capacity In The Perirhinal And Posterior Parietal Cortices Lead To Dissociation Between Attentional, Motivational And Spatial Components Of Exploration In The Naples High Excitability Rat Line

Dr. F. Gonzalez-Lima. - Univ. Texas - gonzalez-lima@psy.utexas.edu United States
Dr. A. Gallo - II University of Naples - agsadile@tin.it Italy
Dr. Adolfo Gustavo Sadile - II University of Naples. - agsadile@tin.it Italy

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(119) Dopamine activation of endogenous cannabinoid signaling in striatum

Dr Andrea Giuffrida - UC Irvine - agiuffri@uci.edu United States
Dr Daniele Piomelli - UC Irvine - piomelli@uci.edu United States

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"IN VITRO" ANIMAL STUDIES

(115) Intrinsic membrane properties and synaptic inputs regulating the firing activity of the dopamine neurons.

Dr Nicola B. Mercuri - IRCCS Santa Lucia, University of Rome Tor Vergata - Mercurin@med.uniroma2.it Italy
Dr Pernilla Grillner - Karolinska Institutet - pernilla.grillner@fyfa.ki.se Sweden

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(120) Regulation of dopamine quantal size in midbrain and hippocampal neurons

Dr Emmanuel N. Pothos - Columbia University - ep155@columbia.edu United States

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(121) Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for ADHD - the spontaneously hypertensive rat (SHR)

Dr Vivienne Russell - University of Cape Town - russell@curie.uct.ac.za South Africa
Mr Siddieq Allie - University of Cape Town - russell@curie.uct.ac.za South Africa
Mrs Toni Wiggins - University of Cape Town - twiggins@anat.uct.ac.za South Africa

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(110) Changes in the Second Messenger cyclic AMP during Development may Underlie Motoric Symptoms in ADHD.

Dr. Susan Andersen - Harvard Medical School - andersen@mclean.org United States

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(117) A Rostro-Caudal Disintegration In Anterior Forebrain Sites Of An Animal Model Of ADHD, The Juvenile SHR: An Hypo Functioning Anterior And Hyper Functioning Posterior Mesolimbic System?

Dr. M. Papa - II Univ. Naples - papa@unina.it Italy
Dr. L. Diewald - II Univ. Naples - papa@unina.it Italy
Dr. F.J. Esposito - II Univ. Naples - papa@unina.it Italy
Dr. M. Pignatelli di Spinazzola - II University of Naples - agsadile@tin.it Italy
Dr. U.A. Gironi Carnevale - II University of Naples - agsadile@tin.it Italy
Dr. Adolfo Gustavo Sadile - II University of Naples. - agsadile@tin.it Italy