Domizio Suvà⁽¹⁾, Isabelle Favre⁽²⁾, Rudolf Kraftsik⁽³⁾, Monica Esteban⁽⁴⁾, Alexander Lobrinus⁽⁵⁾, Judit Miklossy^{(6)
(1)(2)(4)(5)(6)}CHUV, Institute of Pathology - Lausanne. Switzerland
⁽³⁾IBCM - Lausanne. Switzerland

	[Neuroscience]	[Pathology]

INTRODUCTION

Since its first description at the beginning of this century ^(1-6), the clinico-pathologic entity of Alzheimer´s disease (AD) ^(7-9) continues to rise many questions, well summarized in a report of Khachaturian published in 1985 ⁽⁸⁾.

In AD, the involvement of the entorhinal cortex, hippocampus, as well as of the frontal and parietal associative cortical areas is well established ^(10-20). It is generally accepted that the primary motor cortex is less involved or even spared in AD ^(21-28). Only few case reports described severe involvement of the primary motor cortex in AD ^(29,30).

As the reported data are contradictory, the aim of this study was to perform a quantitative analysis of senile plaques and neurofibrillary tangles, to answer the question whether or not the primary motor cortex is involved in AD. The severity of the cortical changes in the primary motor cortex was compared to those of the enthorinal cortex, frontal and parietal associative areas known to be severely involved in AD.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [DISCUSSION] [ACKNOWLEDGEMENTS] [BIBLIOGRAPHY] [Discussion Board]

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	[Neuroscience]	[Pathology]

Domizio Suvà, Isabelle Favre, Rudolf Kraftsik, Monica Esteban, Alexander Lobrinus, Judit Miklossy
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Last update: 14/01/00