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6th Internet World Congress for Biomedical Sciences

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ADP-RIBOSYLATION OF FILAMENTOUS ACTIN INDUCES ITS DEPOLYMERIZATION - THE ROLE OF ADP-RIBOSYLATION IN CYTOSKELETAL REORGANIZATION

Masaharu Terashima(1), Makoto Shimoyama(2), Mikako Tsuchiya(3)
(1)(2)(3)Department of Biochemistry. Shimane Medical University - Izumo. Japan

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS AND DISCUSSION] [FIGURES] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
RESULTS AND DISCUSSION Previous: Testosterone modifies arylamidase activities in serum and different tissues of mice: an in vivo study. Previous: Intrinsic Membrane Properties and Synaptic Inputs Regulating The Firing Activity of the Dopamine Neurons. ACKNOWLEDGEMENTS
[Biochemistry]
Next: An extractable phosphatase inhibitor is present in the CSF of subarachnoid hemorrhage patients with vasospasm 		[Cell Biology & Cytology]
Next: Upregulation of phase II enzymes decreases the oxidative stress induced cell death in astrocytes.

FIGURES

Fig. 1
Fig. 1. ADP-ribosylation of G- and F-actins.

 

Fig. 2
Fig. 2. Effect of ADP-ribosylation on the viscosity of F-actin.

 

Fig. 3
Fig. 3. Schematic representation for the possible effects of ADP-ribosylation of actins on the polymerization-depolymerization state.

In the steady state, G- and F-actins are in dynamic equilibrium (a). When the ADP-ribosylation occurs on G-actin, modified G-actins are no longer integrated into the filamentous form (b). When the ADP-ribosylation occurs on F-actin, its ordered conformation are disrupted and F-actins are gradually depolymerized to the monomeric form (c). Actin is illustrated as a monomeric or filamentous form. ADP-ribose moieties are depicted open circles. Abbreviations of P and D mean polymerization and depolymerization, respectively.

 

Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS AND DISCUSSION] [FIGURES] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
RESULTS AND DISCUSSION Previous: Testosterone modifies arylamidase activities in serum and different tissues of mice: an in vivo study. Previous: Intrinsic Membrane Properties and Synaptic Inputs Regulating The Firing Activity of the Dopamine Neurons. ACKNOWLEDGEMENTS
[Biochemistry]
Next: An extractable phosphatase inhibitor is present in the CSF of subarachnoid hemorrhage patients with vasospasm 		[Cell Biology & Cytology]
Next: Upregulation of phase II enzymes decreases the oxidative stress induced cell death in astrocytes.
Masaharu Terashima, Makoto Shimoyama, Mikako Tsuchiya
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