Poster | 6th Internet World Congress for Biomedical Sciences |
John Cassella(1), Joseph Kelly(2)
(1)(2)School of Radiography & Podiatry. University of Central England - Birmingham. United Kingdom
[Physiology] |
[Neurology] |
[Nutrition & Diabetics] |
• many aspects of the normal response of the foot to injury are reduced or absent in diabetes.
• diabetic neuropathy is thought to have a direct effect on the functioning of the microcirculation
• endothelial cell and smooth muscle integrity in arterioles combined with neuropathic changes have been proposed as a mechanism involved in the pathogenesis of foot ulceration
Aims:
• to study the involvement of peripheral sensory neuropathy in endothelial dependent and endothelial independent vasodilation
• to assess the maximum hyperaemic response to neurogenic stimuli induced by iontophoresis in patients with symmetrical peripheral sensory diabetic neuropathy
• the hypothesis is
– patients with peripheral sensory diabetic neuropathy demonstrate s reduced hyperaemic endothelium dependent and independent vasodilatory response to stimuli
[Physiology] |
[Neurology] |
[Nutrition & Diabetics] |