Bartolomé Quintero⁽¹⁾, María del Carmen Cabeza^(2)
(1)(2)Dpt. Physical Chemistry. Faculty of Pharmacy. University of Granada - Granada. Spain

	[Biophysics]	[Cell Biology & Cytology]

INTRODUCTION

The diethylenetriaminpentaacetic acid (DTPA) in combination with different ions such as In, Tc or Gd is used in several diagnosis/imaging techniques. Moreover, DTPA ability as a chelator is also used in the study of the arenediazonium ions reduction to prevent the action of adventitious reducing metal ions such as Fe²⁺.

The arenediazonium ions are widely employed in chemical synthesis. Apart from the diazocopulation reactions, these ions can undergo either thermal or photochemical heterolytic dediazoniation yielding the aryl cation. Likewise, the arenediazonium ions can be dediazoniated in a homolytic process via monoelectronic reduction which originates the appearance of the aryl radical. The arenediazonium ions are believed to be genotoxic. The electronic structure [Glaser et al., 1999], the dediazoniation mechanism [Pazo Llorente et al., 1999] and the identification of the ultimate genotoxic agent derivated from these ions [Gannett et al., 1999] are aspects currently under investigation.

Some phenolic compounds present in foodstuff, beverage and therapeutical drugs are substrates which can be transformed into the corresponding hydroxybenzenediazonium ions. We have studied the dediazoniation of p-hydroxybenzenediazonium ion (PDQ) in a neutral aqueous medium [Quintero et al., unpublished results]. The dediazoniation process rate decreases in the presence of DTPA. In this paper we report the results obtained in the study of the influence of DTPA in the dediazoniation of PDQ.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS ] [IMAGES] [IMAGES-2] [DISCUSSION] [BIBLIOGRAPHY] [Discussion Board]

---

	[Biophysics]	[Cell Biology & Cytology]

Bartolomé Quintero, María del Carmen Cabeza
Copyright © 1999-2000. All rights reserved.

Last update: 14/01/00