Poster
# 55
Poster |
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6th Internet World Congress for Biomedical Sciences |
Bartolomé Quintero(1), María del Carmen Cabeza(2)
(1)(2)Dpt. Physical Chemistry. Faculty of Pharmacy. University of Granada - Granada. Spain
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Contact address: |
Bartolomé Quintero Dpt. Physical Chemistry Faculty of Pharmacy. University of Granada Campus Universitario de Cartuja s/n Granada Granada 18071 Spain bqosso@platon.ugr.es |
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[Biophysics] |
[Cell Biology & Cytology] |
Diethylenetriaminepentaacetic acid (DTPA) is widely used because of its abitily for chelating different metal ions. Gd-DTPA complexes have been applied in radiometric medical techniques and also in combined antitumour treatments. Likewise, DTPA is commomly used in radical studies as a metal chelator of redox-active metal mostly Fe2+. In the present communication we have studied the DTPA influence on the degradation rate of the p- hydroxybenzenediazonium ion, a recognized genotoxic compound, in neutral aqueous medium (phosphate, pH 7). The experimental data show as an increase of DTPA concentration in solution is followed with a decrease of the PDQ degradation rate. Those effects have been analyzed admitting that the PDQ dediazoniation could take place by means of three different pahtways: i) a homolytic proccess induced by hydroxyl ions ii) a reduction by semiquinone radical and iii) a reduction by hydroquinone. In principle, experimental data seem to rule out a possible ground-state interaction between DTPA and PDQ. Moreover, the oxygen comsuption during the PDQ degradation does not indicate DTPA scavengers oxygen to form complex such as DTPA-Fe2+-O2. We propose a possible interaction of DPTA with the reducing system hydroquinone/semiquinone/quinone in order to explain the observed decrease of the PDQ degradation rate.
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[Biophysics] |
[Cell Biology & Cytology] |
