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6th Internet World Congress for Biomedical Sciences

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Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions.

María Dolores Mayas-Torres(1), José Manuel Martínez-Martos(2), María Jesús Ramírez-Expósito(3), María Jesús García-López(4), Isabel Prieto-Gómez(5), Garbiñe Arechaga-Maza(6), Manuel Ramírez-Sánchez(7)
(1)(2)(4)(5)(6)(7)Unit of Physiology. University of Jaén - Jaén. Spain
(3)Unit of Physiology. University of Jaen - Jaén. Spain

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [IMAGES-2] [DISCUSSION] [BIBLIOGRAPHY] [Discussion Board]
DISCUSSION Previous: Differential effects of 18-Methoxycoronaridine (18-MC) on the behavioural and neurochemical responses to chronic cocaine and morphine: Implications for sensitization in the mediation of drug addiction Previous: Role Of pH In Functioning Of Na<SUP>+</SUP>-Ca<sup>2+</sup> Exchanger In Secretory Cell Plasma Membrane ABSTRACT
[Neuroscience]
Next: Effects of ethanol on aminopeptidase A in cortical synaptosomes.		 [Physiology]
Next: Effects of ethanol on aminopeptidase A in cortical synaptosomes.

BIBLIOGRAPHY

  1. Diamond I, Gordon AS. Cellular and molecular neuroscience of alcoholism. Physiol Rev 1997; 77: 1-20.
  2. Lovinger DM. Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn-Schmiedeberg´s Arch Pharmac 1997; 356: 267-82.
  3. Tabakoff B, Hoffman PL. Alcohol adiction: An enigma among us. Neuron 1996; 16: 909-12.
  4. Tabakoff B, Ellevuo K, Hoffman PL. Alcohol. In Schuster CR, Kuhar MJ, eds. Pharmacological Aspect of Drug Dependence. Handbook of Experimental Pharmacology. Berlín: Springer; 1996: 374-460.
  5. Stone T. Neuropharmacology. New York: Ed. Freeman WH and Company Limited; 1995.
  6. Peoples RW, Weight FF. Cutoff in potency implicates alcohol inhibition of N-methyl-D-aspartate receptors in alcohol intoxication. Proc Natl Acad Sci USA 1995; 92: 2825-9.
  7. Li C, Peoples RW, Weight FF. Alcohol action on a neuronal membrane receptor: evidence for a direct interaction with the receptor protein. Proc Natl Acad Sci USA 1994a; 91: 8200-4.
  8. Fadda F, Rossetti ZL. Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Prog Neurobiol 1998; 56: 385-431.
  9. Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Hoffman PL et al. Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res 1998; 22: 998-1040.
  10. Barrett AJ, Rawlings ND, Woesnner JF. Handbook of Proteolytic Enzimes. Londres: Academic Press; 1998.
  11. Sanderink GJ, Artur Y, Schlele F, Gueguen R, Slest G. Alanine aminopeptidase in serum: Biological variations and reference limits. Clin Chem 1988; 34:1422-6.
  12. Berg MJ, Marks N. Formation of des-tyr-dynorphins-5-17 by a purified cytosolic aminopeptidase of rat brain. J Neurosci Res 1989; 11: 313-21.
  13. Hersh LB. Characterization of membrane bound aminopeptidases from rat brain: Identification of the enkephalin-degrading aminopeptidase. J Neurochem 1985; 44:1427-35.
  14. Wagner GW, Tavianini MA, Herrmann KM, Dixon JE. Purification and characterization of an enkephalin aminopeptidase from rat brain. Biochemistry 1981; 13: 3884-90.
  15. Ahmad S, Ward PE. Role of aminopeptidase activity in the regulation of the pressor activity of circulating angiotensines. J Pharmacol Exp Ther 1990; 252: 643-50.
  16. Johnson GD, Hersh LB. Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase. Arch Biochem Biophys 1990; 276: 305-9.
  17. McDermott JR, Mantle D, Lawfort B, Gibson AM, Biggins A. Purification and characterization of two soluble Cl- activated arginyl aminopeptidase from human brain and their endopeptidase action on neuropeptides. J Neurochem 1988; 50:176-82.
  18. Itoh C, Nagamatsu A. An aminopeptidase activity from porcine kidney that hydrolyzes oxytocin and vasopressin: purification and partial characterization. Biochim Biophys Acta 1995; 1243: 203-8.
  19. Whittaker VP. The synaptosome. In Lajtha A, ed. Handbook of Neurochemistry, 2ª ed. New York: Plenum Press; 1984: 7.
  20. Greenberg LJ. Fluorimetric measurement of alkaline phosphatase and aminopeptidase activities in the order of 10-14 moles. Biochem Biophys Res Commu 1962; 9: 430-5.
  21. Schwabe C, McDonald JK. Demonstration of a pyroglutamyl residue at the N-terminus of the B-chain of porcine relaxin. Biochem Biophys Res Commun 1977; 74: 1501-4.
  22. Schnebli HP, Phillipps MA, Barclay RK. Isolation and characterization of an enkephalin-degrading aminopeptidase from rat brain. Biochim Biophys Acta 1979; 569: 87-98.
  23. Bradford MM. A rapid and sensitive method for quantification of microgram quantities of protein-dye binding. Anal Biochem 1976; 72: 248-54.

Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [IMAGES-2] [DISCUSSION] [BIBLIOGRAPHY] [Discussion Board]
DISCUSSION Previous: Differential effects of 18-Methoxycoronaridine (18-MC) on the behavioural and neurochemical responses to chronic cocaine and morphine: Implications for sensitization in the mediation of drug addiction Previous: Role Of pH In Functioning Of Na<SUP>+</SUP>-Ca<sup>2+</sup> Exchanger In Secretory Cell Plasma Membrane ABSTRACT
[Neuroscience]
Next: Effects of ethanol on aminopeptidase A in cortical synaptosomes.		 [Physiology]
Next: Effects of ethanol on aminopeptidase A in cortical synaptosomes.
María Dolores Mayas-Torres, José Manuel Martínez-Martos, María Jesús Ramírez-Expósito, María Jesús García-López, Isabel Prieto-Gómez, Garbiñe Arechaga-Maza, Manuel Ramírez-Sánchez
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Last update: 15/01/00