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6th Internet World Congress for Biomedical Sciences

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Differential effects of 18-Methoxycoronaridine (18-MC) on the behavioural and neurochemical responses to chronic cocaine and morphine: Implications for sensitization in the mediation of drug addiction

Karen K. Szumlinski(1)
(1)Albany Medical College - Albany. United States

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [FIGURES] [FIGURES-2] [DISCUSSION] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
FIGURES Previous: New bicyclic non-condensited thiazolidones-4 and their cytostatic activity DISCUSSION
[Neuroscience]
Next: Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions.		 [Pharmacology]
Next: Contraindications to thiazides and beta blockers in hypertense patients treated with nifedipine in five Cuban municipalities.		 [Psychiatry]
Next: Augmentation of antidepressant therapy with 5-HT autoreceptor antagonists: receptor autoradiographic studies of pindolol

FIGURES-2

fig. 8
Figure 8. Total stereotypic response of animals treated daily with either SAL or COC. *P<0.05 vs. SAL; +P<0.05 vs. injection 1 (Duncanīs post-hoc tests)

 

fig. 9
Figure 9. Effects of pretreatment with either 18-MC or VEH on the total amount of stereotypy expressed in response to a challenge injection of COC. *P<0.05 vs. VEH (Duncanīs post-hoc tests)

 

fig. 10
Figure 10. Effect of pretreatment with either 18-MC or VEH on the timecourse of stereotypy in response to COC in rats treated chronically with either SAL or COC. *P<0.05 vs. VEH (Duncanīs post-hoc tests)

 

fig. 11
Figure 11. Left: Comparison of the timecourse of extracellular DA in the NAC of rats on injection 1 of repeated MOR treatment versus the test injection, prior to which rats were pretreated with either 18-MC or VEH. Right: Comparison of the extracellular levels of DOPAC (top) and HVA (bottom) during the same microdialysis sessions. *P<0.05 vs. Injection 1; +P<0.05 vs. VEH (Duncanīs post-hoc tests)

 

fig. 12
Figure 12. Effects of 18-MC or VEH on the timecourse of extracellular DA in the NAC of rats treated chronically with either COC (right) or SAL (left) in response to a challenge injection of COC. *P<0.05 vs. SAL; +P<0.05 vs. VEH (Duncanīs post-hoc tests)

 

fig. 13
Figure 13. Comparison of the effects of 18-MC or VEH on the extracellular levels of DOPAC (top) and HVA (bottom) of rats treated chronically with either COC (right) or SAL (left) in response to a challenge injection of COC. *P<0.05 vs. SAL; +P<0.05 vs. VEH (Duncanīs post-hoc tests)

 

Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [FIGURES] [FIGURES-2] [DISCUSSION] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
FIGURES Previous: New bicyclic non-condensited thiazolidones-4 and their cytostatic activity DISCUSSION
[Neuroscience]
Next: Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions.		 [Pharmacology]
Next: Contraindications to thiazides and beta blockers in hypertense patients treated with nifedipine in five Cuban municipalities.		 [Psychiatry]
Next: Augmentation of antidepressant therapy with 5-HT autoreceptor antagonists: receptor autoradiographic studies of pindolol
Karen K. Szumlinski
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Last update: 18/01/00