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6th Internet World Congress for Biomedical Sciences

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Differential effects of 18-Methoxycoronaridine (18-MC) on the behavioural and neurochemical responses to chronic cocaine and morphine: Implications for sensitization in the mediation of drug addiction

Karen K. Szumlinski(1)
(1)Albany Medical College - Albany. United States

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [FIGURES] [FIGURES-2] [DISCUSSION] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
RESULTS Previous: New bicyclic non-condensited thiazolidones-4 and their cytostatic activity FIGURES-2
[Neuroscience]
Next: Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions.		 [Pharmacology]
Next: Contraindications to thiazides and beta blockers in hypertense patients treated with nifedipine in five Cuban municipalities.		 [Psychiatry]
Next: Augmentation of antidepressant therapy with 5-HT autoreceptor antagonists: receptor autoradiographic studies of pindolol

FIGURES

fig. 1
Figure 1. Structure of 18-methoxycoronaridine (18-MC).

 

fig. 2
Figure 2. Effects of pretreatment with 18-MC or VEH on the dose-response relationship for locomotion in rats acutely treated with MOR. *P<0.05 vs. VEH (Duncanīs post-hoc tests)

 

fig. 3
Figure 3. Comparison of the timecourses of locomotor responding to 20 mg/kg MOR in sensitized (right) and non-sensitized (left) rats between injection 1 and injection 5 of chronic MOR treatment. *P<0.05 vs. injection 1 (Duncanīs post-hoc tests)

 

fig. 4
Figure 4. Comparison of the dose-response curves for MOR-induced locomotion of sensitized versus non-sensitized chronic MOR treated rats pretreated with either VEH (left) or 18-MC (right). *P<0.05 vs. non-sensitized (Duncanīs post-hoc tests)

 

fig. 5
Figure 5. Total locomotor response of animals treated daily with either SAL or COC. + P<0.05 vs. injection 1 (Duncanīs post-hoc tests)

 

fig. 6
Figure 6. Composite of the effects of 18-MC or VEH pretreatment on the dose-response curve for total locomotion induced by COC in animals treated chronically with either SAL (left) or COC (right).

 

fig. 7
Figure 7. Effect of pretreatment with either 18-MC (circles) or VEH (squares) on the timecourse of locomotion in response to the various test doses of COC in rats treated chronically with either COC or SAL. *P<0.05 vs. VEH (Duncanīs post-hoc tests)

 

Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [FIGURES] [FIGURES-2] [DISCUSSION] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
RESULTS Previous: New bicyclic non-condensited thiazolidones-4 and their cytostatic activity FIGURES-2
[Neuroscience]
Next: Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions.		 [Pharmacology]
Next: Contraindications to thiazides and beta blockers in hypertense patients treated with nifedipine in five Cuban municipalities.		 [Psychiatry]
Next: Augmentation of antidepressant therapy with 5-HT autoreceptor antagonists: receptor autoradiographic studies of pindolol
Karen K. Szumlinski
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Last update: 18/01/00