leonardo bugatti⁽¹⁾, giorgio filosa⁽²⁾, massimiliano nicolini⁽³⁾, roberto verdolini^(4)
(1)(2)dept of dermatology. "A. Murri" Hospital Jesi - Jesi. Italy
⁽³⁾⁽⁴⁾Dept of Dermatology. "A. Murri" Hospital Jesi - jesi . Italy

	[Dermatology]	[Pathology]

DISCUSSION

Paraffinoma is the result of a foreign body reaction to oily material injected deeply into the cutaneous and subcutaneous tissues for therapeutical, cosmetological or factitial purposes. After an interval of time between the injection and the appearance of skin lesions, the pathologic process goes through different stages: an inflammatory irregular plaque on the site of trauma followed by abscess formation, ulceration and fistulation after many years ⁽¹⁾. From the histologic point of view such lesion is characterized by a sclerosing lipogranuloma evolution with classically "Swiss cheese" appearance.

Verrucous carcinoma (VC) is a low grade and well-differentiated squamous cell neoplasia. Four clinico-pathologic types are described according to the anatomic site of occurrence: i) skin: cutaneous verrucous carcinoma or papillomatosis cutis carcinoides; ii) feet: epithelioma cuniculatum; iii) anogenital: Buschke-Lowenstein tumor; iv) oral: oral florid papillomatosis ⁽²⁾. VC usually presents as a slow growing eso(endophytic mass with high infiltrative power to underlying soft tissue and bone and rarely metastatic potential. Increased evidence over the years have linked VC, mainly Buschke-Loweinstein tumor and epithelioma cuniculatum, to HPV infection with oncogenic potential (3,4). HPV infection can facilitate VC because of oncogene expression. Differential diagnosis of VC includes pseudoepitheliomatous hyperplasia and viral warts. VC can rarely develope in the site of chronic skin ulcers of varicous, traumatic, decubitus, burn or radiodermititis origin after a long period (20-34 years). In general spindle cell carcinoma is believed to be at increased risk of relapse and/or metastases once it developes from chronic cutaneous ulcer, with an overall survival rate of 52 and 34% at five and ten years follow-up respectively ^(5,6).

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [CASE REPORT] [DISCUSSION] [IMAGES] [BIBLIOGRAPHY] [Discussion Board]

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	[Dermatology]	[Pathology]

leonardo bugatti, giorgio filosa, massimiliano nicolini, roberto verdolini
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Last update: 23/12/99