Nº 048

IICVHAPp.gif (9537 bytes)

gbritaip.gif (244 bytes)


Efecto de Tacrolimus® y Ciclosporina A sobre la Expresión de Glicoproteína P en Células Tubulares Renales en Cultivo.

[Título] [Introducción] [Material y Métodos] [Resultados] [Discusión] [Iconografía]


1 - Biedler JL, Riehm H. Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic and cytogenetic studies. Cancer Res 1970;30:1174-1184.

2 - Ueda K, Clark DP, Chen CJ, Roninson IB, Gottesman MM, Pastan IH. The human multidrug-resistance (mdr1) gene: cDNA cloning and transcription initiation. J Biol Chem 1987;262:505-508.

3 - Gros P, Ben Neriah Y, Croop JM, Housman DE. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 1986;323:728-731.

4 - Roninson IB, Chin JE, Choi K, Gros P, Housman DE, Fojo A, Shen DW, Gottesman MM, Pastan I. Isolation of human mdr DNA sequences amplified in multidrug-resistance KB carcinoma cells. Proc Natl Acad Sci USA 1986;83:4538-4552.

5 - Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I. Genetic analysis of the multidrug transporter. Annu Rev Genetics 1995;29:607-649.

6 - Higgins CF. ABC transporters: from microorganisms to man. Annu Rev Cell Biol 1992;8:67-113.

7 - Devault A, Gros P. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol 1990;10:1652-1663.

8 - Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993;62:385-427.

9 - Germann UA, Chambers TC, Ambudkar SV, Licht T, Cardarelli CO, Pastan I, Gottesman MM. Characterization of phosphorylation defective mutants of human P-glycoprotein expressed in mammalian cells. J Biol Chem 1996;271:1708-1716.

10 - Bourhis J, Goldstein L, Riou G, Pastan I, Gottesman MM, Benard J. Expression of a multidrug resistance gene mdr1 in ovarian carcinomas. Cancer Res 1989;49:5062-5065.

11 - Twentyman PR. Cyclosporins as drug resistance modifiers. Biochem Pharmacol 1992;43:109-117.

12 - Broeks A, Gerrard B, Allikmets R, Dean M, Plasterk RHA. Homologes of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J 1996;15:6132-6143.

13 - Cordon-Cardo C, O'Brien JP, Casals D, Bertino JR, Melamed MR. P-glycoprotein expression in human tumors and normal tissues. J Histochem Cytochem 1990;38:1277-1281.

14 - García Del Moral R, O'Valle F, Andújar M, Aguilar M, Lucena MA, López-Hidalgo J, Ramírez C, Medina-Cano MT, Aguilar D, Gómez-Morales M. Relationship between P-glycoprotein expression and cyclosporin A in kidney. An immunohistological and cell culture study. Am J Pathol 1995;146:398-408.

15 - Leveille-Webster CR, Arias IM. The biology of the P-glycoproteins. J Membrane Biol 1995;143:89-102.

16 - Ernst S, Belloreuss E. Xenobiotic transport differences in mouse mesangial cell clones expressing Mdr1 and Mdr3. Am J Physiol 1996;39:C910-C919.

17 - Bennett WM, Demattos A, Meyer MM, Andoh T, Barry JM. Chronic Cyclosporine nephropathy: The Achilles` heel of immunosuppresive therapy. Kidney Int 1996;50:1089-1100.

18 - Lanning CL, Fine RL, Sachs CW, Rao US, Corcoran JJ, Aboudonia MB. Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein. J Toxicol Env Health 1996;47:395-407.

19 - Gaush CR, Hard WL, Smith TF. Characterization of an established line of a canine kidney cells (MDCK). Pro Soc Exp Biol Med 1966;122(3):931-935.

20 - Hull RN, Cherry WR, Weaver GW. The origins of a pig kidney cell strain. In Vitro 1976;12:670-677.

21 - Perantoni A, Berman JJ. Properties of Wilms' tumor line (TuWi) and pig kidney line (LLC-PK1) typical of normal kidney tubular epithelium. In Vitro 1979;15(6):446-454.

22 - Cardarelli CO, Aksentijevich I, Pastan I, Gottesman MM. Differential effects of P-Glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transports. Cancer Res 1995;55:1086-1091.

23 - Plumb JA, Milroy R, Kaye SB. Effects of the pH of 3-[4,5-dimetiltiazol-2-il]-2,5-difenil-tetrazolium bromide-formazan absortion on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res 1989;49:4435-4440.

24 - García Del Moral R, O'Valle F, Andújar M, Aguilar M, Lucena MA, López-Hidalgo J, Ramírez C, Medina-Cano MT, Aguilar D, Gómez-Morales M. Relationship Between P-Glycoprotein Expression And Cyclosporin A In Kidney. An Immunohistological And Cell Culture Study. Am J Pathol 1995;146:398-408.

25 - Kute TE, Quadri Y. Measurement of proliferation nuclear and membrane markers in tumor cells by flow cytometry. J Hitochem Cytochem 1991;39:1125-1130.

26 - Seamer LC, Babcock GF, Duque R. Measurement of DNA. En: Robinson JP, editor. Handbook of flow cytometry methods. New York: Wiley-Liss, 1993:90-126.

27 - Hedley DW. Assays of the cancer chemotherapy resistance. En: Robinson JP, editor. Handbook of flow cytometry methods. New York: Wiley-Liss, 1993:191-193.

28 - Gant TW, Silverman JA, Thorgeirsson SS. Regulation of P-glycoprotein gene expression on hepatocyte cultures and liver cells lines by a trans-acting transcripcional repressor. Nucleic Acids Res 1992;20:2841-2846.

29 - Thorgeirsson SS, Huber BE, Sorrel S, Fojo AT, Pastan I, Gottesman MM. Expression of the Multidrug-Resistant Gene in hepatocarcinogenesis and regenerative rat liver. Science 1987;236:1120-1122.

30 - Marino PA, Gottesman MM, Pastan I. Regulation of the multidrug resistance gene in regenerating rat liver. Cell Growth Differ 1990;1:57-62.

31 - Corrias MV, Tonini GP. An oligomer complementary to the 5' end region of mdr1 gene decreases resistance to doxorubicin of human adenocarcinoma-resistant cells. Anticancer Res 1992;12:1431-1438.

32 - Ogura M, Takatori T, Tsuruo T. Purification and characterization of NF-R1 that regulates the expression of the human multidrug resistance (mdr1) gene. Nucleic Acids Res 1992;20:5811-5817.

33 - Takatori T, Ogura M, Tsuruo T. Purification and characterization of NF-R2 that regulates the expression of the human multidrug resistance (mdr1) gene. Jpn J Cancer Res 1993;84:298-303.


[Título] [Introducción] [Material y Métodos] [Resultados] [Discusión] [Iconografía]

Francisco Arrebola, MS.
Copyright © 1996, Departamento de Anatomía Patológica, Facultad de Medicina y Hospital Universitario, Universidad de Granada, 18012 Granada, España. Reservados todos los derechos.