Phyllis G. Paterson^(1)
(1)University of Saskatchewan - Saskatoon. Canada

CONCLUSIONS

These studies suggest that the maintenance of brain GSH is an important determinant of the extent of secondary tissue damage in stroke. Strategies to enhance GSH in brain should be tested for their therapeutic efficacy in the human condition of stroke. Our studies of depletion of brain GSH by acute sulfur amino acid deficiency may have practical significance. Ongoing studies will determine whether more clinically relevant states such as fasting and chronic protein-energy malnutrition have similar effects that can be reversed by the administration of GSH delivery agents. Protein-energy depletion, which is known to decrease GSH in other tissues ^(31-33), has been documented in 16% or more of elderly patients at the time of admission for acute stroke -reviewed in ⁽⁵⁷⁾-.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [CENTRAL ROLE OF GLUTATHIONE IN STROKE] [MODULATION OF BRAIN GLUTATHIONE IN STROKE] [IMAGES] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [BIBLIOGRAPHY] [Discussion Board]

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Phyllis G. Paterson
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Last update: 13/01/00