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6th Internet World Congress for Biomedical Sciences

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Augmentation of antidepressant therapy with 5-HT autoreceptor antagonists: receptor autoradiographic studies of pindolol

Trevor Sharp(1), Elena Castro(2)
(1)Department of Clinical Pharmacology. University of Oxford - Oxford. United Kingdom
(2) Clinical Pharmacology. University of Oxford - Oxford. United Kingdom

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [FIGURES] [DISCUSSION] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
DISCUSSION Previous: GENTAMICIN CONTAINING SURGICAL BONE CEMENT: IN VITRO ELUTION CHARACTERISTICS OF PALACOS® AND PALAMED® Previous: Differential effects of 18-Methoxycoronaridine (18-MC) on the behavioural and neurochemical responses to chronic cocaine and morphine: Implications for sensitization in the mediation of drug addiction ACKNOWLEDGEMENTS
[Pharmacology]
Next: Effects Of Long Term Treatment With Amlodipine Or Nebivolol In SHRs. 		[Psychiatry]
Next: Central Neurochemical Alterations Induced by Acute and Repeated Systemic Interleukin-2 Administration

CONCLUSIONS

In conclusion, our results show that the putative SSRI augmenting agent, (±)-pindolol, has high affinity for both presynaptic and postsynaptic 5-HT1A receptors in postmortem human and rat brain. Our data do not support the idea that pindolol has marked selectivity for any of the 5-HT1A receptor populations studied in vitro. However, recent PET imaging studies in human volunteers indicate that over a narrow dose range, pindolol may preferentially occupy presynaptic 5-HT1A receptors in vivo (13). Whether this property of pindolol confers therapeutic advantages (ie. in major depression) over other 5-HT1A receptor antagonists currently available for clinical use (eg. tertatolol and penbutolol), awaits further investigation.

Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [FIGURES] [DISCUSSION] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
DISCUSSION Previous: GENTAMICIN CONTAINING SURGICAL BONE CEMENT: IN VITRO ELUTION CHARACTERISTICS OF PALACOS® AND PALAMED® Previous: Differential effects of 18-Methoxycoronaridine (18-MC) on the behavioural and neurochemical responses to chronic cocaine and morphine: Implications for sensitization in the mediation of drug addiction ACKNOWLEDGEMENTS
[Pharmacology]
Next: Effects Of Long Term Treatment With Amlodipine Or Nebivolol In SHRs. 		[Psychiatry]
Next: Central Neurochemical Alterations Induced by Acute and Repeated Systemic Interleukin-2 Administration
Trevor Sharp, Elena Castro
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