Poster
# 98
Poster |
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6th Internet World Congress for Biomedical Sciences |
Alberto Pizarro Gallardo(1)
(1)Facultad de Medicina U.A.N. - Tepic. Mexico
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[Urology] |
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[Pathology] |
The term "oncocyte" was introduced by Hamperl(1). He identified the oncocytes by their abundant, finaly granular acidophilic cytoplasm found most often in salivary glands, lacrimal glands, and various endocrine organs.
Oncocytomas are a rare variant of renal adenoma with abundant eosinophilic cytoplasm and a central fibrous scar. They account for less than 7 % of renal neoplasm.(2-3) Most affected patients are asymptomatic and the lesion is usually incidentally detected.(3-4)
Paraganglioma Cchemodectoma) are tumors arising in or around the sympathetic ganglia, outside the adrenal medulla. It is an extramedullary pheochromocytoma. The tumor have similar histological features and prognosis to pheochromocytomas.(5-7)Paraganglioma have essential or paroxysmal hypertension, sometimes sweating and palpitations.
Histological features: Oncocytomas are cytoplasmic granularity by large numbers of mitochondria. there is not glycogen and are PAS- negative. Ultrastructurally, oncocytoma cells contain large number of mitochondria.(2-4,7-8)
Paraganglioma have haemorrhagic foci and cyst. The tumor have catecholamines; they can be demostrated with dichromate fixatives. its cells have basophilic and granular cytoplasm. its pathological diagnosis was by immunohistochemestry.(5-7)
In the present report, we described two neoplasm resected: kidney oncocytoma and abdominal paraganglioma.
We reported a 39 year-old woman with 2 months of low abdominal pain, pirosis, regurgitation, and abdominal tumor since at 3 years. The tumor with size of 25 cm was fixed and unpain., headache, loss weight by 10 kg. and left lymph node. Hyperthension of 150/110 sometimes. X-ray films revealed a mass distorting the left kidney with hidronefrosis and calcification.
There was not clinical or laboratory evidence of endocrine dysfunction.
Histologic sections of formalin- fixed paraffin - embedded material were stained with hematoxylin - eosin, PAS, gree orange G, and Masson thricomic methods. Immunocytochemical stain for noradrenaline hormone were used.Also electron microscopy methods were used.
A left radical nephrectomy was performed. The kidney weisghed 1050 grams. The tumor have 25x15 cm in diameter yellow-brown with cyst areas with haemorrhagic.(Fig1) There was not normal kidney and no invasion of the renal capsule. Histologically, the tumor was found to be an oncocytic adenoma.(Fig2)
Other tumor was find and resected in the organs of Zuckerkandl.The solid tumor of 150 grams. Tumor hace 7x5 cm with capsule and diffuse haemorrhagic.(Fig3) Histologically, the tumor was one paraganglioma.
Electron microscopy revealed that oncocytoma was composed predominatly of typical oncocytes: cells with ovoid to round, frequently notched or indented nuclei and cytoplasm virtually filled with crowded hyperplastic mitochondria.(Fig4)
Kidney oncocytomas are generally regarded as very uncommon neoplasm and associated with paraganglioma are more uncommon. The oncocytic transformation of kidney cells is unkwonwn. The association of two neoplasm may to be clasified in the syndrome of multiple endocrine adenoma maybe type II.
The oncocytoma is identified in light microscopy by their abundant, finely granular acidophilic cytoplams and in electron microscopy by their abundants mitochondrias. The paraganglioma is diagnosed as adenoma y had neurosecretories granules.
This report is the first in the association of these two tumors.
We decribed two benign neoplasm :
1. Kidney oncocytoma histologically and ultrastructurally demostrated.
2. Paraganglioma in Zuckerkandl histologically and immunocytochemistry demostrated.
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[Urology] |
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[Pathology] |
