Toshihiro Yorozuya⁽¹⁾, Naoto Adachi⁽²⁾, Masao Soutani⁽³⁾, Kazuo Nakanishi⁽⁴⁾, Kentaro Dote⁽⁵⁾, Shigeo Kimura⁽⁶⁾, Takumi Nagaro⁽⁷⁾, Tatsuru Arai^{(8)
(1)(2)(3)(7)(8)}Ehime-university School of Medicine - Japan
^(4)(5)(6)Ehime university School of Medicine - Japan

	[Pharmacology]	[Cardiolovascular Diseases]

RESULTS

The temperature of the temporal muscle measured after decapitation in the saline and dexamethasone groups was 37.8 ± 0.4 and 37.6 ± 0.4 degree C (mean +/- SD, n=6), respectively. No difference was observed between the dexamethasone and saline groups.

With respect to the ATP concentration, there were no differences between the two groups when the hearts were frozen immediately after removal (Fig. 1). The values were 1568 +/- 470 and 1727 +/- 259 nmol/g (mean +/- SD), respectively. Hypoxia for 5 minutes decreased ATP content to 330 +/- 130 nmol/g in the saline group. However, the extent of the ATP decrease caused by 5 minutes of hypoxia was significantly suppressed in the dexamethasone group. The ATP level was 1085 +/- 296 nmol/g. Although the long duration of hypoxia further lowered the ATP content in each group, no differences were found between the two groups after 10 or 20 minutes of hypoxia.

Similar to the decrease in ATP levels, heart ADP content decreased during hypoxia. Pretreatment with dexamethasone suppressed the extent of ADP decrease and, after 5 minutes of hypoxia, the effect was significant compared to the saline group (Fig. 2). In the dexamethasone group, the AMP content at 5 minutes of hypoxia was significantly low compared with that in the saline group (Fig. 3).

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [FIGURES] [DISCUSSION] [CONCLUSIONS] [BIBLIOGRAPHY] [Discussion Board]

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	[Pharmacology]	[Cardiolovascular Diseases]

Toshihiro Yorozuya, Naoto Adachi, Masao Soutani, Kazuo Nakanishi, Kentaro Dote, Shigeo Kimura, Takumi Nagaro, Tatsuru Arai
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Last update: 14/01/00