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6th Internet World Congress for Biomedical Sciences

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Effects of ethanol on aminopeptidase A in cortical synaptosomes.

María Dolores Mayas-Torres(1), José Manuel Martínez-Martos(2), María Jesús Ramírez-Expósito(3), María Jesús García-López(4), Isabel Prieto-Gómez(5), Garbiñe Arechaga-Maza(6), Manuel Ramírez-Sánchez(7)
(1)(2)(4)(5)(6)(7)Unit of Physiology. University of Jaén - Jaén. Spain
(3)Unit of Physiology. University of Jaen - Jaén. Spain

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [DISCUSSION] [BIBLIOGRAPHY] [Discussion Board]
DISCUSSION Previous: Role Of pH In Functioning Of Na<SUP>+</SUP>-Ca<sup>2+</sup> Exchanger In Secretory Cell Plasma Membrane Previous: Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions. Previous: Contraindications to thiazides and beta blockers in hypertense patients treated with nifedipine in five Cuban municipalities. Previous: Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions. ABSTRACT
[Endocrinology]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.		 [Neuroscience]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.		 [Pharmacology]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.		 [Physiology]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.		 [Toxicology]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.

BIBLIOGRAPHY

  1. McKeon UG, O´Connor B. Mammalian pyroglutamyl-peptidase I. En Barrett AJ, Rawlings ND, Woesnner JF, editores. Handbook of Proteolytic Enzimes. Londres: Academic Press, 1998: 796-797.
  2. Alba F, Ramírez M, Cantalejo ES, Iribar C. Aminopeptidase activity is asymetrically distributed in selected zones of rat brain. Life Sci 1988; 43: 935-939.
  3. Mc Geer PL, Mc Geer EG. Amino acid neurotransmitters. En Siegel GI et al., editores. Neurochemistry. New York: Raven Press, 1989: 311-332.
  4. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. New Engl J Med 1994; 330: 613-622.
  5. Coyle JT. Neurotoxic action of kainic acid. J Neurochem 1983; 41: 1-11.
  6. Frandsen A, Schousboe A. Development of excitatory amino acid induced cytotoxicity in cultured neurons. Int J Dev Neurosci 1990; 8: 209-216.
  7. Choi DW. Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. TINS 1988; 11: 465-469.
  8. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988; 1: 623-634.
  9. Choi DW. Excitotoxicity cell death. J Neurobiol 1992; 23: 1261-1266.
  10. Choi DW, Hartley DM. Calcium and glutamate-induced cortical neuronal death. En Waxman SG, editor. Molecular and cellular approaches to the treatment of neurological disease. New York: Raven Press, 1993: 23-34.
  11. Olney JW, Ho OL, Rhee V. Cytotoxic effects of acidic, sulphur containing amino acids on the infant mouse central nervous system. Exp Brain Res 1971; 14: 61-76.
  12. Miyashita K, Abe H, Nakajima T, et al. Glutamate release in gerbil hippocampus after middle cerebral artery occlusion. Neuroreport 1994; 5: 945-948.
  13. Dichter MA, Choi DW. Excitatory amino acid neurotransmitters and excitotoxins. Curr Neurol 1989; 9: 1-26.
  14. Whittaker VP. The synaptosome. En Lajtha A, editor. Handbook of Neurochemistry, 2ª ed. New York: Plenum Press, 1984; 7.
  15. Schwabe C, McDonald JK. Demonstration of a pyroglutamyl residue at the N-terminus of the B-chain of porcine relaxin. Biochem Biophys Res Commun 1977; 74: 1501-1504.
  16. Bradford MM. A rapid and sensitive method for quantification of microgram quantities of protein-dye binding. Anal Biochem 1976; 72: 248-254.
  17. Martínez JM, Prieto I, Ramírez MJ, De Gasparo M, Hermoso F, Arias JM, Alba F, Ramírez M. Sex differences and age-related changes in human serum aminopeptidase A activity. Clin Chim Acta 1998; 274: 53-61.
  18. Cheung HS, Cushman DW. A soluble aspartato aminopeptidase from dog kidney. Biochim Biophys Acta 1971; 242: 190-193.
  19. Duggan J, Nussberger J, Kilfeather S, O´Malley K. Aging and human hormonal and pressor responsiveness to angiotensin II. Am J Hypertens1993; 6: 641-647.
  20. Jung YS, Lee S, Shin HS. Effects of age on angiotensin II response and antagonistic activity of losartan in rat aorta and liver. Arch Pharmacol Res 1996; 19: 462-468.
  21. Michel JB, Heudes D, Michel O. Effect of chronic Ang I-converting enzyme inhibition on ageing processes. II. Large arteries. Am J Physiol 1994; 267: 124-135.
  22. García SI, Dabsys SM, Martínez VN, Dolorenz A, Santajuliana D, Nahmod VE, Frinkielman S, Pirola CJ. Tyrotropin releasing hormone hyperactivity in the preoptic area of spontaneously hypertensive rats. Hypertension 1995; 26: 1105-1110.
  23. Phillips MI, Speakman EE, Kimura B. Levels of angiotensin and molecular biology of the tissue renin angiotensin system. Reg Peptides 1993; 43: 1-20.
  24. Ahmad S, Ward PE. Role of aminopeptidase activity in the regulation of the pressor activity of circulating angiotensins. J Pharmacol Exp Ther1990; 252: 643-650.

Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [DISCUSSION] [BIBLIOGRAPHY] [Discussion Board]
DISCUSSION Previous: Role Of pH In Functioning Of Na<SUP>+</SUP>-Ca<sup>2+</sup> Exchanger In Secretory Cell Plasma Membrane Previous: Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions. Previous: Contraindications to thiazides and beta blockers in hypertense patients treated with nifedipine in five Cuban municipalities. Previous: Effects of ethanol on brain aminopeptidase activities under basal and K+-stimulated conditions. ABSTRACT
[Endocrinology]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.		 [Neuroscience]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.		 [Pharmacology]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.		 [Physiology]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.		 [Toxicology]
Next: In vitro study on the effect of ethanol on basal and stimulated pyroglutamyl aminopeptidase activity in mouse brain.
María Dolores Mayas-Torres, José Manuel Martínez-Martos, María Jesús Ramírez-Expósito, María Jesús García-López, Isabel Prieto-Gómez, Garbiñe Arechaga-Maza, Manuel Ramírez-Sánchez
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Last update: 15/01/00