Karen K. Szumlinski^(1)
(1)Albany Medical College - Albany. United States

	[Neuroscience]	[Pharmacology]	[Psychiatry]

CONCLUSIONS

Pretreatment with the potential anti-addictive drug, 18-MC, increases the potency of both MOR and COC to induce behaviour hyperactivity in rats acutely treated with these addictive substances. These effects are not related to alterations in accumbal DA transmission. In chronic MOR and COC treated rats, 18-MC exerts opposite effects on the potency of these two drugs to induce sensitized levels of motor responding; 18-MC blocks and potentiates, respectively, the expression of MOR and COC locomotor sensitization. Whereas the interaction between MOR and 18-MC in the sensitized rats may involve a blockade of DA sensitization in the NAC, the interactions between 18-MC and COC appear to be non-DAergic. Given that 18-MC effectively blocks the self-administratoin of both MOR and COC, the neural mechanisms through which 18-MC exerts its anti-addictive effects likely involves the ability to reset or reverse the neuroadaptations in the mesolimbic DA system produced by chronic drug self-administration, implicating a role for DA sensitization in the mediation of drug addiction.

Discussion Board

Any Comment to this presentation?

[ABSTRACT] [INTRODUCTION] [MATERIALS AND METHODS] [RESULTS] [FIGURES] [FIGURES-2] [DISCUSSION] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]

---

	[Neuroscience]	[Pharmacology]	[Psychiatry]

Karen K. Szumlinski
Copyright © 1999-2000. All rights reserved.

Last update: 18/01/00