Poster
# 8
Poster |
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6th Internet World Congress for Biomedical Sciences |
Francisco Martín Dávila(1), Marcial García Rojo(2), Jesus Gonzalez Garcia(3), Margarita Delgado Portela(4), Rafael López Pérez(5), Manuel Carbajo Vicente(6)
(1)(2)(3)(4)(5)(6)Servicio de Anatomía Patológica. Complejo Hospitalario de Ciudad Real - Ciudad Real. Spain
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Contact address: |
Francisco Martín Dávila Servicio de Anatomía Patológica Complejo Hospitalario de Ciudad Real Hospital Alarcos Avda Pìo XII, s/n Ciudad Real Ciudad Real 13002 Spain solepac@retemail.es |
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[Obstetrics & Gynecology] |
[Oncology] |
[Pathology] |
INTRODUCTION
Although described more frequently in other locations, mainly related with cholesteatoma of ear, cholesterol granuloma is a very rare entity in mammary gland that clinical or macroscopically can be mistaken with malignant tumors.
CASE REPORT
The patient was a woman of 70 years old without previous relevant clinical history that suffered of mastodinia on her right mammary gland. Palpation reveled a deep and ill-defined mass in supper-external cuandrant. Under mammographic study, two well-delineated solid masses with a hypoechoic content similar to oleossus cysts were demonstrated. No microcalcifications were observed.
Macroscopically, two mammary fragments each of them with a nodular tumor of 2,8x2x1,7 cm. and 1 cm. respectively were sent to our Service. They were very well demarcated from adjacent fatty tissue with a shinny brown cut surface. They had a firm consistency and a gritty texture (Fig. 1).
Imprints show crystals with irregular and many times trapezoidal contours negative under polarized light and scattered macrophages (Fig 2).
On histologic sections, many large and irregular aggregates of tightly packed cholesterol needle-like crystals in parallel or radial arrays were observed in both tumors (Fig. 3).
Collagen bands containing macrophages and foreign-body giant cells were noted between crystal aggregates (Fig. 4). Both tumors were delineated by a fibrocolagenous band of variable thickness.
There were focal hemosiderin deposits but no microcalcifications were observed.
In adjacent mammary tissue there were distended ectatic ducts containing foamy histocytes, calcium deposits and immersed in a fibrous stroma (Fig 5). No other significant mammary pathology were noted.
COMMENTARY
Cholesterol granuloma is a very infrequent entity in mammary gland and because of its clinical, radiological and macroscopic appearance can be mistaken with malignant neoplasms, a problem easily resolved under microscopic study.
Firstly reported in this location in 1974 [1] its pathogenesis is still in dispute although because of the frequent association of this pathology with mammary duct ectasia some researchers suggest that it is a sequela of the rupture of ectatic ducts into the periductal parenchyma [2,3].
REFERENCES
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[Obstetrics & Gynecology] |
[Oncology] |
[Pathology] |
