Poster
# 3
Poster |
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6th Internet World Congress for Biomedical Sciences |
Kazuo Emi(1)
(1)Emi Eye Clinic - Yokkaichi. Japan
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[Ophthalmology] |
Many glaucoma studies have confirmed that high intraocular pressure is the most important risk facter for the disease. However, many patients seem to develop the disease with normal and occasionally low pressures. It should be considered that there must be other risk factors for the glaucoma. The normal IOP can damage the optic nerve which has considerably vulnerable to the hydrostatic pressure. An acute ischemia in the optic nerve causes anterior ischemic optic neuropathy. It is often said that the chronic ischemia in the optic nerve may cause NTG. Some NTG patients have Raynaud´s phenomenon, migrane or coldness of the hands or feet1,2. But most NTG patients have no systemic blood circulation disturbance. I think the insufficient ocular blood supply is an important risk factor among the other causative factors 3. The peripheral vascular resistence of the NTG patients is grater than that of normal controls in this experiment. At the end-diastolic phase of the heart, the low systemic blood pressure and high ocular peripheral vascular resistance might cause the insufficient ocular blood supply in NTG patients to certain extent. Such circulatory disturbance is apparently harmful for NTG patients with regard to the blood supply to the optic nerve. This study shows that its quite important to maintain the ocular blood circulation especially such NTG patients.
I believe the usage of betaxolol is the first choice for such type of the NTG patient because betaxolol is a beta-1 blocker which doesn´t have the vasoconstrictive effect and prohibit the calcium influx into the vessel´s endothelium resulting dilating the ocular peripheral vasculatures 4,5,6. The second choice, I think, is the usage of the unoprostone eye drops which improve the ocular blood circulation and no vasoconstrictive effect 7,8,9,10,.
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[Ophthalmology] |
