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6th Internet World Congress for Biomedical Sciences

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Contraindications to thiazides and beta blockers in hypertense patients treated with nifedipine in five Cuban municipalities.

Juan Antonio Furones(1), Angel Lopez(2), Ana Rodriguez(3), Frank Debesa(4), Carmen Portuondo(5)
(1)(5)Centro para el Desarrollo de la Farmacoepidemiologia - Ciudad Habana. Cuba
(2)(3)(4)Pharmacoepidemiology Development Center - Havana. Cuba

Discussion Board Contact address: Juan Antonio Furones
Centro para el Desarrollo de la Farmacoepidemiologia
Ciudad Habana
Ciudad Habana 10 700 Cuba
furones@mcdf.sld.cu
[ABSTRACT] [Discussion Board]
Main Page Previous: Differential effects of 18-Methoxycoronaridine (18-MC) on the behavioural and neurochemical responses to chronic cocaine and morphine: Implications for sensitization in the mediation of drug addiction Previous: Morphometric study of the coronary atherosclerosis in autopsy of diabetic, hypertensive and diabetics and hipertensive subjects.<br>(Análisis morfométrico de la aterosclerosis de las arterias coronarias en fallecidos diabéticos, hipertensos y diabéticos e hipertensos) ABSTRACT
[Pharmacology]
Next: Effects of ethanol on aminopeptidase A in cortical synaptosomes.		 [Cardiolovascular Diseases]
Next: Reduced energy consumption by dexamethasone in the mouse heart.

ABSTRACT

Introduction: short acting nifedipine is frequently used in primary care in Cuba, even cardiovascular morbidity and mortality are not improved by this treatment.

Objectives: Determine the proportion of hypertense patients treated with nifedipine related with contraindications to thiazides and betablockers.

Materials and methods: In five municipalities of Havana City a drug utilization study, transverse and descriptive was performed. Sample was calculated by each participant municipality, being patients randomly allocated from drug prescriptions certificates in the drug stores, with nifedipine prescribed in the first semester of 1998.

Results: 58.5% were female, 75,5% were white and 43.3% older than 65 years. 1106 patients (73,6%) had no contraindications to diuretics and betablockers. 281 patients (18.7%) had contraindications for thiazides and betablockers, 42 (2,8%0 to diuretics and 74 (4,9%) to both drugs.

Discussion: There is a bad habit in nifedipine prescription in Cuba, demonstrated in this study, even it´s well known it enhances the AMI risk, thus the importance of good drug prescriptions practices.

Conclusions: 26,4% of the patients presented associated pathologies which contraindicated the use of thiazidics and beta blockers to treat hypertension, thus over 70% of the interviewed patients are not benefited of the protector role of these drugs. The highest use of nifedipine might be determined by larger disponibility of the drug in pharmacies.

Keywords: contraindications - nifedipine - thiazides - beta blockers - anti hypentensive -
Discussion Board
Discussion Board

Any Comment to this presentation?

[ABSTRACT] [Discussion Board]
Main Page Previous: Differential effects of 18-Methoxycoronaridine (18-MC) on the behavioural and neurochemical responses to chronic cocaine and morphine: Implications for sensitization in the mediation of drug addiction Previous: Morphometric study of the coronary atherosclerosis in autopsy of diabetic, hypertensive and diabetics and hipertensive subjects.<br>(Análisis morfométrico de la aterosclerosis de las arterias coronarias en fallecidos diabéticos, hipertensos y diabéticos e hipertensos) ABSTRACT
[Pharmacology]
Next: Effects of ethanol on aminopeptidase A in cortical synaptosomes.		 [Cardiolovascular Diseases]
Next: Reduced energy consumption by dexamethasone in the mouse heart.
Juan Antonio Furones, Angel Lopez, Ana Rodriguez, Frank Debesa, Carmen Portuondo
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