Paper # 096 Versiˇn en Espa˝ol Spanish version

Thymic microenvironmental changes in human congenital syphilis

Eliene C. Fonseca, M˘nica P. Almeida, ╔vlin H. Maia, Dora M. F. Menezes and Wilson Savino*

[Title] [Introduction] [Materials and Methods] [Discussion] [Pictures] [Bibliography]

Materials & Methods

Pictures

RESULTS

 

Thymic Pathology :
  • Organ atrophy
  • Thymocyte depletion
  • Intra-thymic B cells
  • Changes in ECM
  • Altered pattern of cortical and medullary TEC network
  • Extramedullary hematopoiesis
Thymic Extracellular matrix :
  • Septal space enlargement
  • Thickened basement membrane
  • Basement membrane Ig deposits
  • Novel intraseptal space
  • Intralobular ECM expression

 

Lymphocyte depletion X Septal enlargement

Cases

Sex

Age

* Lymphocyte depletion

**Septal enlargement

1

M

Stillborn

+++

++++

2

M

Stillborn- 28wk

+++

++++

3

F

Stillborn- 35 wk

+++

++++

4

M

Stillborn- 32 wk

+++

+++

5

F

Stillborn- 26 wk

+++

+++

6

F

Newborn

+++

+++

7

F

Newborn- 35 wk

++

++

8

M

Stillborn - 24 wk

++

+

9

M

Stillborn - 37 wk

+

+

10

F

Stillborn

++

0

11

M

Stillborn - 27 wk

+

++

12

M

Newborn -33 wk

+

0

13

M

Stillborn

+

+

14

F

Newborn- 35 wk

+

0

 

* Lymphocyte Depletion
+ mild
++ moderate
+++ severe
 
** Septal enlargment
0 normal
+ mild
++ moderate
+++ severe, without septal "projections"
++++ severe, with septal "projections"

 


Materials & Methods

Pictures