Paper # 010 Versión en Español Versión en Español

Liver metastasis of oncocytic carcinoid: cytohistological, immunohistochemical and ultrastructural study.


Teresa Ribas Ariño, Elena García Lagarto, Nieves Alonso Orcajo, Santos Salas Valién, Asunción González Morán.

Pathology Department. Hospital de León. León. Spain.

Address: Altos de Nava s/n.
224080 León. Spain


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Morphological findings in the fore mentioned fields are analyzed in a hepatic mass, initially detected by radiological imaging, in a 73 years old male, that 5 years earlier has a surgical operation of an oncocytic carcinoid of the lung.
A fine needle aspiration of the liver was performed. It was diagnosed of carcinoid tumor, with positive immunochemistry for neuron specific enolase (NSE) and chromogranin. Afterwards, the patient went on surgery.
The excised mass was 4 x 3 x 3 cm; its morphological characteristics were the same as the previous tumor, with cells that showed an eosinophilic granular cytoplasm and a central nucleus, arranged in nests or rows
The neoplastic cells were positive with NSE, chromogranin and synaptophysin. In the ultrastructural examination, a large number of mitochondria and neurosecretion granules were found.
All these findings led to the diagnosis of oncocytic carcinoid tumor, after excluding the possibilities of a hepatocarcinoma and other tumors.

Dr. Teresa Ribas Ariño is .........

Hospital de León ............

Key Words: Oncocytic carcinoid , Liver, Fine needle aspiration, Lung

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