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6th Internet World Congress for Biomedical Sciences

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DIFFERENT ANXIOLYTIC EFFECTS OF DIAZEPAM IN FISCHER 344 RATS AND TWO STOCKS OF WISTAR RATS IN THE ELEVATED PLUS MAZE

Bettina Bert(1), Andre Rex(2), Heidrun Fink(3)
(1)Institute of Pharmacology and Toxicology. Humboldt-University Berlin, Charite - Berlin. Germany
(2)Institute of Pharmacology and Toxicology. VB Vterinary medicine, Free University - Berlin. Germany
(3)Institute of Pharmacology and Toxicology. School of Veterinary Medicine, Free University Berlin - Berlin. Germany

Discussion Board Contact address: Bettina Bert
Institute of Pharmacology and Toxicology Humboldt-University Berlin, Charite
Berlin
D-10098 Germany
bettina.bert@charite.de
[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
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ABSTRACT

The study of anxiety-related behaviour is complicated by strain differences. The behaviour of untreated animals and the response to drugs in animal tests of anxiety vary between strains, even when identical tests are used. It is an aim to determine the influence of the genotype on behaviour for the assessment of genetically manipulated animals in the future. Therefore, the knowledge of the behaviour of different rat strains is indispensable. In the present study Fischer 344 rats (F344/NHsd, HarlanWinkelmann) and two stocks of Wistar rats (Hsdcpd:WU, HarlanWinkelmann and Crl:[WI]BR, Federal Instiute for Healthprotection of consumers and Veterinary medicine) were examined in the elevated plus maze-test aFTer intraperitoneal application of diazepam (0.5-4.0 mg/kg, 30 min before testing) to assess the contribution of genetic background to anxiety-motivated behaviour. The results show plain differences in the anxiety-related behaviour of the groups treated with saline in the elevated plus maze. Harlan-Wistar rat seem to be less anxious than FIHV-Wistar rats and Harlan-Fischer rats. Additionally, the anxiolytic effect of diazepam was more pronounced in Harlan-Fischer rats and FIHV-Wistar rats. As well, the most effective doses of diazepam was lower in the Harlan-Fischer rats (1 mg/kg) compared to the FIHV-Wistar rats (2 mg/kg) and Harlan-Wistar rats (4 mg/kg). The strain (stock) differences seem to have a large impact not only on the anxiety-associated behaviour of untreated animals, but also on the effect of anxiolytic drugs. Supported by BMBF (01 ZZ 9511)

Keywords: Strain differences - anxiety - diazepam - metabolism - rats -
Discussion Board
Discussion Board

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[ABSTRACT] [INTRODUCTION] [MATERIAL & METHODS] [RESULTS] [IMAGES] [CONCLUSIONS] [ACKNOWLEDGEMENTS] [REFERENCES] [Discussion Board]
Main Page Previous: The Neurophysiology of Hypnosis: Hypnosis as a State of Selective Attention and Disattention. Previous: PREPARATION OF A 5% FLURBIPROFEN HYDROGEL: Pharmaceutical aspects INTRODUCTION
[Neuroscience]
Next: Neural Networks for the Detection of EEG Arousal During Sleep.		 [Pharmacology]
Next: Determination of the Protection Level for Post Chemotherapy Emesis with a Multilayer Perceptron.
Bettina Bert, Andre Rex, Heidrun Fink
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