Poster
# 57
Poster |
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6th Internet World Congress for Biomedical Sciences |
Margot M.S. Naaijkens(1), A.A. van Sorge(2)
(1)Rijnstate Hospital - ARNHEM. Netherlands
(2)Rijnstate Hospital Arnhem - ARNHEM. Netherlands
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Contact address: |
Margot M.S. Naaijkens Rijnstate Hospital Wagnerlaan 55 ARNHEM Gld 6814 KX Netherlands M.M.S.Naaijkens@students.pharm.uu.nl |
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[Pharmacology] |
[Dermatology] |
The objective is to prepare a transparant flurbiprofen hydrogel with good consistency. The formulation of several commercial ibuprofen hydrogels was used as a starting point. In the examined hydrogels, isopropyl alcohol and benzyl alcohol, are used as preservative agents. In our flurbiprofen hydrogel another preservative, Kathon CG®, is used. To optimize microbiological conservation the pH value is of importance (preferably < 7). Therefore solubility characteristics of flurbiprofen and ibuprofen were investigated in a pH range of 3.5 to 7.5 (pKa flurbiprofen: 4.2; pKa ibuprofen: 5.2). Complete solubility is expected at 2 pH units above either pKa. Results indicate that flurbiprofen and ibuprofen dissolve above pH 6.8 and pH 6.6 respectively. A complicating factor is the solubility of flurbiprofen sodium (about 0.5%). A 5% flurbiprofen solution can be obtained by using equimolar quantities of N-methyl-glucamine (meglumine) and flurbiprofen. The pH of the flurbiprofen-meglumine solution is adjusted with HCl to pH 6.8. Results of use of Tromethamine as base were negative.
Adherence is influenced by consistency. As a thickening agent hydroxyethyl cellulose is used. High consistency however is accompanied by disadvantages like clotting during preparation and loss of cosmetical appearance.
The present status of the developed 5% flurbiprofen hydrogel is a transparent gel (pH 6.8) with median consistency. The in vitro-release of flurbiprofen from the hydrogel will be examined.
Zaman M, McAllister M, Martini LG and Lawrence MJ
The Physico-Chemical and Biological factors influencing bioadhesion
Biopharm Europe 1999;11:52-60
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[Pharmacology] |
[Dermatology] |
