Poster
# 10
Poster |
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6th Internet World Congress for Biomedical Sciences |
Francisca Mulero(1), V. Roca(2), F. Nicolás(3), Francisca Mulero(4), J.A. Nuño de la Rosa(5)
(1)(4)(5)Hospital Universitario Virgen de la Arrixaca - San Miguel de Salinas. Spain
(2)(3)Servicio de Medicina Nuclear. Hospital Universitario Virgen de la Arrixaca (Murcia) - Murcia. Spain
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Contact address: |
Francisca Mulero Hospital Universitario Virgen de la Arrixaca San Miguel de Salinas Alicante 03193 Spain mulerof@teleline.es |
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[Oncology] |
[Radiology & Nuclear Medicine] |
99mTc-MIBI breast scintigraphy is the proposed tumor-seeking agent for the diagnostic imaging of a variety of human malignant tumors. Although its usefulness in breast carcinomas is beyond discussion, certain kinds of tumors do not show 99mTc-MIBI uptake. At present, the mechanism by which it concentrates in malignant tissue is not clear. The aim of our study was to determine the correlation between 99mTc-MIBI uptake and histopathological parameters of tumoral aggressiveness. We studied 84 patients with breast cancer. All of them underwent breast scintimammography with 99mTc-MIBI with semiquantitative analysis by means of tumor-to-background ratios calculated in every projection. After surgery, an experienced pathologist determined tumor size, axillar lymph node metastases, histological degree (Scarff Bloom Richardson), nuclear degree, mitotic index, cellular atypia and oestrogen receptor expression. Results: threre is an statistically significant correlation (p< 0.05) between tumor-to-background (T/B) ratios of 99mTc-MIBI uptake and tumor SCBR histological degreee. We also found correlation between 99mTc-MIBI uptake and the mitotic index, cellular atypia and nuclear degree. In our study we found no correlation with tumor size, oestrogen receptor expression or axillar lymph node metastases.
Conclusions: 99mTc-MIBI uptake in breast carcinomas correlates with tumoral differentiation degree: the less differentiated the higher uptake. However, we found no correlation with the main histological parameters that define tumoral aggressiveness.
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[Oncology] |
[Radiology & Nuclear Medicine] |
