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Long-Term Side Effects Opioids interfere with normal function of the lungs and put those who abuse opioids at a greater risk of pneumonia. Those who use or abuse opioids have the potential to develop a condition known as narcotic bowel syndrome, which results from a person's bowel function slowing. Narcotic bowel syndrome causes symptoms like bloating, vomiting, constipation, abdominal distention, and nausea. Medications can assist with discomfort caused by the syndrome.

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What Are the Side Effects of Hydrocodone? Hydrocodone use can cause various side effects, even with legitimate medical use. The most common side effects include nausea and vomiting. The drug may also cause constipation since opioids have the potential to reduce how fast it takes stool to move through the digestive system. In addition, opioids like hydrocodone increase nonpropulsive contractions in the middle of the small intestines and lessen the motions in the intestines that are responsible for moving food through them. The drug also has the potential to cause food to remain in the body's organs for longer than usual as well as cause a reduction in digestive secretions and the urge to defecate.

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