Internet Virtual Slide Congress

Virtual Slide Congress. Case # 08

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Mercedes García Villanueva*, María García Martos*, Mª Eugenia Reguero Callejas*
* Hospital Ramón y Cajal. Madrid ESPAÑA
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Clinical history    

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Female 22 years old presented a back pain and left leg weakness of 8 months of evolution.

Magnetic resonance imaging revealed and intradural extramedullary tumour at L1-L2 which displaced spinal roots to the left.

 
OlympusThis slide's been digitized with Olympus/SIS dotslide system
Preparación digitalizada con el sistema Olympus/SIS dotslide
H&E
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Diagnosis 
Clear cell meningioma (Meningioma de células claras)
Schwannoma
Neurofibroma
Ependymoma (Ependimoma)
Drop metastasis from a pineoblastoma (Metástasis de pinealoblastoma)


FINAL DIAGNOSIS IS BELOW THIS LINE
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Pathology diagnosis    

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CLEAR CELL MENINGIOMA

 
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Pathology findings    

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MAIN PATHOLOGIC FINDINGS
Histologically the tumour showed sheets of cells having clear polygonal cytoplasm rich in glycogen, with round, uniform and bland-appearing nuclei without mitosis. No whorls, clear cytoplasmic inclusions or psammomatous bodies were observed. The stroma displayed prominent collagen bundles of varying size, closely associated with the tumour cells.
Immunohistochemically, the tumour cells were positive for vimentin and epithelial membrane antigen and negative for cytokeratin, S-100 and glial fibrillary acidic protein.

 
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References    

-Liu PI, Liu GC., Tsai KB, Lin CL, Hsu JS. Intrspinal clear-cell meningioma: case report and review of literature. Surg Neurol 2005; 63:285-8.
 
- Oviedo A., Pang D., Zovickian J., Smith M. Clear cell meningioma: case report and review of the literature. Pediatr Dev Pathol 2005; 8:386-90.
 
- Carlotti CG , Neder L, Colli BO, dos Santos MB, García AS, Elías J, Chimelli LC.Clear cell meningioma of the fourth ventricle. Am J Surg Pathol 2003; 27:131-135.

 
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Comments

- Ernesto Blanco Blanco (29/10/2005 12:23:22)

Realmente una rareza, sobre todo la localización. Las células claras recuerdan un poco las del seminoma. Felicidades!!!

- Mirta Garcia Jardon (29/10/2005 13:47:08)

Congratulations for such interesting case. We have had one recently but of angiomatous variant.

- Javier Muñoz Moreno (31/10/2005 13:38:58)

Raro e interesante. Felicidades.

- HUGO GÓNGORA JARA (09/11/2005 3:49:44)

Muy interesante. Llama la atención la presencia de linfocitos. Felicidades.

- LILIA MARGARITA BERNAL MONDRAGÓN (11/11/2005 7:14:58)

Precioso caso; encontré una calcosfera, lo que aunado a los nidos de células claras me ayudo sustancialmente a establecer el diagnóstico.

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