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Pathology findings
fiogf49gjkf0d Histologically, there is a proliferation of fusiform cells with high cell density areas and a slightly fasciculate pattern. Other areas show less cellular density in a myxoid, highly vascularized stroma, with areas of necrosis and hemorrhage.
Neoplastic cells show fusiform and oval nuclei, with a high mitotic count, ill defined cytoplasmic borders, and fibrillar appearance. Occasionally, cytoplasmic striations can be observed, as well as large brightly eosinopilic cytoplasms, with a rhabdomyoblastic appearance.
Immunohistochemical study showed tumoral cells expressing marked staining with vimentin, specific muscle actin , and CD34+, and a focal and weak positivity to CD68. S100 and low cytokeratin markers were negative.
Microscópicamente estaba constituida por una proliferación de células fusiformes mostrando áreas de mayor densidad y patrón discretamente fasciculado, alternando con otras , de disposición mas laxa y estroma de aspecto fibromixoidc ricamente vascularizado con áreas de necrosis y hemorragia.
La celularidad mostraba unos núcleos fusiformes y ovalados, con frecuentes figuras de mitosis, limites citoplasmáticos mal definidos y aspecto fibrilar, identificándose ocasionalmente estriaciones citoplasmáticas y elementos celulares de amplio citoplasma intensamente eosinófilo y aspecto rabdomioblástico.
Con las técnicas inmunohistoquímicas la celularidad expresa intensa positividad para Vimentina, actina muscular específica y CD 34+, focal y debil positividad a CD68, y negatividad para S100 y CK 18.
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